Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28644955 | 0.98 | HPGD (0.50) | KDM4EHPGDMAPTKMT2AMEN1 | |
| SCHEMBL69400 | 0.86 | SMN1; SMN2 (0.60) | KDM4EHPGDMAPTKMT2AMEN1 | |
| SCHEMBL11649636 | 0.84 | HPGD (0.59) | KDM4EHPGDMAPTKMT2AMEN1 | |
| SCHEMBL18039474 | 0.84 | RPA1 (0.52) | KDM4EMAPTCYP1A2TP53GAA | |
| SCHEMBL25078330 | 0.83 | HPGD (0.51) | KDM4EHPGDMAPTKMT2AMEN1 | |
| SCHEMBL7268 | 0.83 | KMT2A (0.68) | MAPTKMT2AMEN1ALDH1A1POLB | |
| SCHEMBL8614979 | 0.83 | ALDH1A1 (0.51) | KDM4EHPGDMAPTKMT2AMEN1 | |
| SCHEMBL13239857 | 0.83 | RPA1 (0.70) | KMT2AMEN1SMN1; SMN2L3MBTL1FAAH | |
| SCHEMBL5311716 | 0.83 | CNR1 (0.47) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL28625965 | 0.82 | KMT2A (0.67) | MAPTKMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126023-B | Pyrazole amide compound as well as preparation method and application thereof | 安徽中医药大学 | 2025-04-11 | — | — | CN | disclosed |
| CN-119264054-B | Pyrazolecarboxylic acid borneol ester compound and preparation method and application thereof | 安徽中医药大学 | 2025-04-01 | — | — | CN | disclosed |
| CN-118724871-B | Pyrazolone-tacrine compound and preparation method and application thereof | 安徽中医药大学 | 2025-01-28 | — | — | CN | disclosed |
| CN-119264054-A | Pyrazolecarboxylic acid borneol ester compound and preparation method and application thereof | 安徽中医药大学 | 2025-01-07 | — | — | CN | disclosed |
| CN-118724871-A | Pyrazolone-tacrine compound and preparation method and application thereof | 安徽中医药大学 | 2024-10-01 | — | — | CN | disclosed |
| CN-118126023-A | Pyrazole amide compound as well as preparation method and application thereof | 安徽中医药大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-104640847-B | Novel Renin Inhibitors | 上海医药集团股份有限公司 | 2019-10-15 | — | — | CN | disclosed |
| US-9556159-B2 | Renin inhibitor | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-01-31 | — | — | US | disclosed |
| US-9556159-B2 | Renin inhibitor | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2017-01-31 | — | — | US | disclosed |
| EP-2933248-A1 | NOVEL RENIN INHIBITOR | Mitsubishi Tanabe Pharma Corporation (JP) | 2015-10-21 | — | — | EP | disclosed |
| US-20150232459-A1 | NOVEL RENIN INHIBITOR | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-08-20 | — | — | US | disclosed |
| US-20150232459-A1 | NOVEL RENIN INHIBITOR | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2015-08-20 | — | — | US | disclosed |
| CN-104640847-A | Novel Renin Inhibitors | SHANGHAI PHARMACEUTICALS HOLDING CO LTD | 2015-05-20 | — | — | CN | disclosed |
| EP-1239009-B1 | Process for the preparation of asymmetric methine dyestuffs | LANXESS DEUTSCHLAND GMBH (DE) | 2009-08-12 | — | — | EP | disclosed |
| US-20080269293-A1 | PYRAZOLE DERIVATIVES AS ANTI-PLATELET AND ANTI-THROMBOTIC AGENTS | PFIZER INC. | 2008-10-30 | — | — | US | disclosed |
| US-20080269293-A1 | PYRAZOLE DERIVATIVES AS ANTI-PLATELET AND ANTI-THROMBOTIC AGENTS | PFIZER INC. | 2008-10-30 | — | — | US | disclosed |
| US-4837335-A | Process for the preparation of pure 1-phenyl-3-carbalkoxy-5-hydroxypyrazoles | CHEMIE LINZ G.M.B.H. (AT) | 1989-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232459-A1 | NOVEL RENIN INHIBITOR | REN, AGTR1, ACE | KDM4E 1425/4885HPGD 1094/4885MAPT 4303/4885 |
| US-20080269293-A1 | PYRAZOLE DERIVATIVES AS ANTI-PLATELET AND ANTI-THROMBOTIC AGENTS | P2RY1, P2RY11, P2RX7 | KDM4E 3700/4885HPGD 1548/4885MAPT 4693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.