Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.54 |
| ▸ | SCD | O00767 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | PRKX | P51817 | 1/20 | 0.51 |
| ▸ | NEK2 | P51955 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10579325 | 0.90 | DGAT1 (0.51) | DGAT1KCNH2NPBWR1SCDCHEK1 | |
| SCHEMBL10577479 | 0.88 | NPBWR1 (0.67) | DGAT1KCNH2NPBWR1SCDTRPV1 | |
| SCHEMBL10576089 | 0.87 | NPBWR1 (0.64) | DGAT1KCNH2NPBWR1SCDTRPV1 | |
| SCHEMBL10573947 | 0.86 | NPC1 (0.58) | DGAT1KCNH2NPBWR1SCDTRPV1 | |
| SCHEMBL10575692 | 0.85 | NPBWR1 (0.49) | DGAT1KCNH2NPBWR1SCDTRPV1 | |
| SCHEMBL10573910 | 0.85 | SLC2A1 (0.62) | NPBWR1TRPV1CHEK2MEN1KMT2A | |
| SCHEMBL10577338 | 0.81 | DGAT1 (0.57) | DGAT1KCNH2NPBWR1SCDCHEK1 | |
| SCHEMBL10579204 | 0.81 | ALOX5 (0.62) | NPBWR1TRPV1CHEK2ALDH1A1HPGD | |
| SCHEMBL10578018 | 0.79 | DGAT1 (0.62) | DGAT1KCNH2NPBWR1ALDH1A1HPGD | |
| SCHEMBL10577412 | 0.78 | F2 (0.41) | DGAT1KCNH2NPBWR1SCDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |