SCHEMBL10579

SCHEMBL10579

C[C@@](CCc1ccc(-c2ccccc2)cc1)(C(=O)NO)S(C)(=O)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 1.00
MMP12 P39900 1/20 1.00
MMP13 P45452 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16511763 1.00 SLC6A2 (1.00) SLC6A2MMP12MMP13
SCHEMBL16511332 0.92 SLC6A2 (0.85) SLC6A2MMP12MMP13
SCHEMBL16512859 0.91 SLC6A2 (0.83) SLC6A2MMP12MMP13
SCHEMBL16512677 0.90 SLC6A2 (0.81) SLC6A2MMP12MMP13
SCHEMBL17435767 0.89 SLC6A2 (0.81) SLC6A2MMP12MMP13
SCHEMBL12071 0.89 SLC6A2 (0.81) SLC6A2MMP12MMP13
SCHEMBL17435717 0.89 SLC6A2 (0.81) SLC6A2MMP12MMP13
SCHEMBL11898857 0.88 SLC6A2 (0.79) SLC6A2MMP12MMP13
SCHEMBL5740 0.86 SLC6A2 (0.76) SLC6A2MMP12MMP13
SCHEMBL11045 0.86 SLC6A2 (0.75) SLC6A2MMP12MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140364398-A1 C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents PFIZER INC. (US) 2014-12-11 US claimed
US-8853258-B2 C-linked hydroxamic acid derivatives useful as antibacterial agents PFIZER INC. (US) 2014-10-07 US claimed
US-20120202777-A1 C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents BROWN MATTHEW FRANK (US) 2012-08-09 US claimed
US-20260115279-A1 Methods for Isolation of Lipid-Disc Compositions and Uses Thereof VIB VZW (BE) 2026-04-30 US disclosed
EP-4396206-A1 METHODS FOR ISOLATION OF LIPID-DISC COMPOSITIONS AND USES THEREOF VIB VZW (BE) 2024-07-10 EP disclosed
WO-2023031205-A1 METHODS FOR ISOLATION OF LIPID-DISC COMPOSITIONS AND USES THEREOF VIB VZW (BE) 2023-03-09 WO disclosed
US-20140364398-A1 C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents PFIZER INC. (US) 2014-12-11 US disclosed
US-20140364398-A1 C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents PFIZER INC. (US) 2014-12-11 US disclosed
US-8853258-B2 C-linked hydroxamic acid derivatives useful as antibacterial agents PFIZER INC. (US) 2014-10-07 US disclosed
US-8853258-B2 C-linked hydroxamic acid derivatives useful as antibacterial agents PFIZER INC. (US) 2014-10-07 US disclosed
EP-2488489-A2 C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS Pfizer Inc. (US) 2012-08-22 EP disclosed
US-20120202777-A1 C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents BROWN MATTHEW FRANK (US) 2012-08-09 US disclosed
US-20120202819-A1 COMBINATION THERAPY USING A BETA 3 ADRENERGIC RECEPTOR AGONISTS AND AN ANTIMUSCARINIC AGENT MERCK SHARP & DOHME CORPORATION (US) 2012-08-09 US disclosed
WO-2011045703-A2 C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS PFIZER INC. (US) 2011-04-21 WO disclosed
WO-2011045703-A2 C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS PFIZER INC. (US) 2011-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120202777-A1 C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents HAX1, LPXN, AGXT SLC6A2 4624/4885MMP12 482/4885MMP13 549/4885
US-20120202819-A1 COMBINATION THERAPY USING A BETA 3 ADRENERGIC RECEPTOR AGONISTS AND AN ANTIMUSCARINIC AGENT ADRB2, ADRB3, ADRA2A SLC6A2 103/4885MMP12 1416/4885MMP13 1835/4885
US-20260115279-A1 Methods for Isolation of Lipid-Disc Compositions and Uses Thereof STT3B, DDOST, PLTP SLC6A2 2960/4885MMP12 2395/4885MMP13 4226/4885
US-20140364398-A1 C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents LCT, AGXT, PRXL2A SLC6A2 4292/4885MMP12 138/4885MMP13 332/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.