Glutarate

Glutarate

SCHEMBL10600593

Nc1ccc(O)cc1.O=C(O)CCCC(=O)O

nearest known ligand 0.56

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.56
CYP3A4 P08684 2/20 0.56
CASP1 P29466 2/20 0.56
HSD17B10 Q99714 2/20 0.56
HIF1A Q16665 2/20 0.56
THRB P10828 2/20 0.56
CA3 P07451 1/20 0.56
ALOX15 P16050 1/20 0.56
CA6 P23280 1/20 0.56
CA14 Q9ULX7 1/20 0.56
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
SLC22A6 Q4U2R8 2/20 0.48
CYP1A1 P04798 1/20 0.46
APP P05067 3/20 0.45
CA2 P00918 1/20 0.45
CAMK2A Q9UQM7 1/20 0.45
ESR1 P03372 1/20 0.44
ESR2 Q92731 1/20 0.44
KMT2A Q03164 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adipic Acid SCHEMBL29044502 0.86 LMNA (0.58) ALDH1A1CASP1HSD17B10HIF1ATHRB
Dodecanoate SCHEMBL27709113 0.85 GPR84 (0.59) ALDH1A1HSD17B10ALOX15SLC22A6APP
Octanoic Acid SCHEMBL27562486 0.85 GPR84 (0.59) ALDH1A1HSD17B10ALOX15SLC22A6APP
Stearic Acid SCHEMBL299703 0.85 GPR84 (0.59) ALDH1A1HSD17B10ALOX15SLC22A6APP
4-Aminophenol SCHEMBL16670828 0.83 ALDH1A1 (0.52) ALDH1A1CYP3A4CASP1HSD17B10HIF1A
4-Aminophenol SCHEMBL11151700 0.82 ALDH1A1 (0.62) ALDH1A1CYP3A4CASP1HSD17B10HIF1A
Succinic Acid SCHEMBL6544596 0.81 LMNA (0.53) ALDH1A1CYP3A4CASP1HSD17B10HIF1A
Succinic Acid SCHEMBL27434396 0.81 LMNA (0.53) ALDH1A1CYP3A4CASP1HSD17B10HIF1A
4-Aminophenol SCHEMBL27835004 0.81 ALDH1A1 (0.77) ALDH1A1CYP3A4CASP1HSD17B10HIF1A
Glutarate SCHEMBL28110215 0.79 HDAC3 (0.58) ALDH1A1CA3CA14NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0095229-B1 ACETAMINOPHEN ANALOGS, ANTIGENS, AND ANTIBODIES SYVA COMPANY (US) 1989-03-15 EP disclosed