SCHEMBL1061027

SCHEMBL1061027

CC(=O)OC[C@H]1O[C@@H](n2cnc3c(=O)nc(N)[nH]c32)[C@H](OC(C)=O)[C@@H]1OC(C)=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.58
▸ LMNA P02545 3/20 0.58
▸ MAPT P10636 3/20 0.58
▸ TP53 P04637 1/20 0.58
▸ TDP1 Q9NUW8 1/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.52
▸ THRB P10828 1/20 0.52
▸ HIF1A Q16665 1/20 0.52
▸ PRKAB2 O43741 1/20 0.47
▸ PRKAG1 P54619 1/20 0.47
▸ PRKAA2 P54646 1/20 0.47
▸ PRKAA1 Q13131 1/20 0.47
▸ PRKAG3 Q9UGI9 1/20 0.47
▸ PRKAG2 Q9UGJ0 1/20 0.47
▸ PRKAB1 Q9Y478 1/20 0.47
▸ HINT1 P49773 2/20 0.44
▸ PRKCA P17252 1/20 0.42
▸ AKT1 P31749 1/20 0.42
▸ PTK2 Q05397 1/20 0.42
▸ CA1 P00915 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1061031 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL13462039 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL1120690 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL14144174 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL278167 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL25407962 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL13296251 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL3422978 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL4386265 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1
SCHEMBL314536 0.85 ALDH1A1 (0.68) ALDH1A1LMNAMAPTTP53TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE TEAM MEDICAL, LLC 2025-09-18 — — US disclosed
WO-2024097262-A1 CHEMOPROTEOMIC CAPTURE OF RNA BINDING ACTIVITY IN LIVING CELLS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2024-05-10 — — WO disclosed
EP-1947092-B1 Method for producing nucleic acid base having perfluoroalkyl group TOSOH CORP (JP) 2015-04-15 — — EP disclosed
US-8362203-B2 Non-natural peptides as models for the development of antibiotics WAYNE STATE UNIVERSITY (US) 2013-01-29 — — US disclosed
US-7884202-B2 Nucleobases are perfluoroalkylated in a one step process with a perfluoroalkyl halide in the presence of a sulfoxide, a peroxide and an iron compound; useful as medicinal drugs, intermediates for medicinal drugs and agricultural chemicals TOSOH CORPORATION (JP) 2011-02-08 — — US disclosed
US-20110021748-A1 Non-Natural Peptides as Models for the Development of Antibiotics WAYNE STATE UNIVERSITY (US) 2011-01-27 — — US disclosed
US-20090124796-A1 Nucleobase Having Perfluoroalkyl Group and Process for Producing the Same TOSOH CORPORATION (JP) 2009-05-14 — — US disclosed
EP-1947092-A1 NUCLEIC ACID BASE HAVING PERFLUOROALKYL GROUP AND METHOD FOR PRODUCING THE SAME Tosoh Corporation (JP) 2008-07-23 — — EP disclosed
US-6951932-B2 Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC. (US) 2005-10-04 — — US disclosed
US-20030199686-A1 Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2003-10-23 — — US disclosed
EP-0670845-B1 PROCESS FOR THE PREPARATION OF FLUDARABINE PHOSPHATE FROM GUANOSINE SCHERING AG (DE) 1998-01-14 — — EP disclosed
US-5668270-A Process for the preparation of fludarabine or fludarabine phosphate from guanosine SCHERING AKTIENGESELLSCHAFT (DE) 1997-09-16 — — US disclosed
US-5602246-A Process for the preparation of fludarabine or fludarabine phosphate from guanosine SCHERING AKTIENGESELLSCHAFT (DE) 1997-02-11 — — US disclosed
EP-0664294-A1 Production of nucleoside analogues Reese, Colin (GB) 1995-07-26 — — EP disclosed
US-5412088-A 6-O-substituted guanosine derivatives RUTGERS, THE STATE UNIVERSITY (US) 1995-05-02 — — US disclosed
US-4689404-A Production of cytosine nucleosides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1987-08-25 — — US disclosed
EP-0193903-A2 Production of cytosine nucleosides Takeda Chemical Industries, Ltd. (JP) 1986-09-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030199686-A1 Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines AMPD2, ADAR, ADA ALDH1A1 2143/4885LMNA 2588/4885MAPT 4862/4885
US-20110021748-A1 Non-Natural Peptides as Models for the Development of Antibiotics MRPL21, SPOUT1, EMG1 ALDH1A1 3405/4885LMNA 2736/4885MAPT 3463/4885
US-20250289840-A1 RNA STABILIZING SUBSTANCES AND METHODS OF USE SYNCRIP, SNRPA, RNASE1 ALDH1A1 1153/4885LMNA 240/4885MAPT 953/4885
US-20090124796-A1 Nucleobase Having Perfluoroalkyl Group and Process for Producing the Same PFAS, FPGS, NUDT1 ALDH1A1 2255/4885LMNA 2811/4885MAPT 4013/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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