Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9379275 | 0.81 | POLB (0.30) | POLB | |
| SCHEMBL181548 | 0.80 | MEN1 (0.47) | POLBGAAMEN1KMT2APTGS1 | |
| SCHEMBL3059892 | 0.78 | GAA (0.51) | POLBGAAALDH1A1SMN1; SMN2PTGS2 | |
| SCHEMBL5309397 | 0.77 | ALOX5 (0.48) | CYP1A2MAPTSMN1; SMN2ALOX5PDE4A | |
| SCHEMBL5997170 | 0.72 | MGLL (0.45) | GAAMEN1KMT2APTGS1ALDH1A1 | |
| SCHEMBL20703296 | 0.70 | PDE3B (0.41) | MEN1KMT2APTGS1ALDH1A1KDM4E | |
| SCHEMBL8688176 | 0.70 | ITGB3 (0.37) | ALOX12 | |
| SCHEMBL9462156 | 0.69 | L3MBTL1 (0.42) | POLBMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL20703110 | 0.69 | PDE3B (0.43) | SHMT2 | |
| SCHEMBL20703202 | 0.68 | GAA (0.42) | GAAPTGS1MAPTSMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661917-B1 | 6-((3-TRIFLUOROMETHYL)PHENYL)-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | BAYER AG (DE) | 2022-05-11 | — | — | EP | disclosed |
| EP-0084250-B1 | 6-(SUBSTITUTED PHENYL)-4,5-DIHYDRO-3-(2H)-PYRIDAZINONE COMPOUNDS AND PROCESSES FOR THEIR PREPARATION | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1988-06-22 | — | — | EP | disclosed |
| EP-0089528-B1 | 6-ARYL-4,5-DIHYDRO-3(2H)-PYRIDAZINONES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1987-05-27 | — | — | EP | disclosed |
| US-4544562-A | 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, and their use as anti-hypertensive and anti-thrombocyte agents | BASF AKTIENGESELLSCHAFT (DE) | 1985-10-01 | — | — | US | disclosed |
| EP-0088128-A4 | ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES. | DIAMOND SHAMROCK CORP (US) | 1984-04-06 | — | — | EP | disclosed |
| EP-0089528-A1 | 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, their preparation and use | BASF Aktiengesellschaft (DE) | 1983-09-28 | — | — | EP | disclosed |
| EP-0088128-A1 | ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES | DIAMOND SHAMROCK CORPORATION (US) | 1983-09-14 | — | — | EP | disclosed |
| WO-1983000863-A1 | ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES | DIAMOND SHAMROCK CORP (US) | 1983-03-17 | — | — | WO | disclosed |
| EP-0018063-B1 | PYRIDAZIN (2H)-3-ONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN ANTIHYPERTENSIVE AGENTS | DIAMOND SHAMROCK CORPORATION (US) | 1983-02-23 | — | — | EP | disclosed |
| US-4238490-A | Antihypertensive pyridazin(2H)-3-ones | DIAMOND SHAMROCK CORPORATION (US) | 1980-12-09 | — | — | US | disclosed |
| EP-0018063-A1 | Pyridazin (2H)-3-ones, process for their preparation and their use in antihypertensive agents | DIAMOND SHAMROCK CORPORATION (US) | 1980-10-29 | — | — | EP | disclosed |