Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103524 | 0.79 | — | — | |
| SCHEMBL323509 | 0.79 | — | — | |
| SCHEMBL130778 | 0.72 | ITGB2 (0.39) | ITGB2ICAM1ITGAL | |
| SCHEMBL9466531 | 0.68 | — | — | |
| SCHEMBL4753114 | 0.67 | — | — | |
| SCHEMBL4753165 | 0.67 | — | — | |
| SCHEMBL29788643 | 0.66 | MAOA (0.41) | ITGB2ICAM1ITGAL | |
| SCHEMBL895328 | 0.66 | MAOA (0.41) | ITGB2ICAM1ITGAL | |
| SCHEMBL29788642 | 0.66 | MAOA (0.41) | ITGB2ICAM1ITGAL | |
| SCHEMBL107468 | 0.66 | MAOA (0.41) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483255-B1 | PROCESS FOR SYNTHESIZING CHIRAL N-ARYL PIPERAZINES | WYETH CORP (US) | 2009-08-12 | — | — | EP | claimed |
| US-7256289-B2 | Process for making chiral 1,4-disubstituted piperazines | WYETH (US) | 2007-08-14 | — | — | US | claimed |
| US-7091349-B2 | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | WYETH (US) | 2006-08-15 | — | — | US | claimed |
| US-7019137-B2 | Process for making chiral 1,4-disubstituted piperazines | WYETH (US) | 2006-03-28 | — | — | US | claimed |
| US-20050228181-A1 | Process for making chiral 1,4-disubstituted piperazines | WYETH (US) | 2005-10-13 | — | — | US | claimed |
| EP-1483256-A2 | PROCESS FOR MAKING CHIRAL 1,4-DISUBSTITUTED PIPERAZINES | Wyeth (US) | 2004-12-08 | — | — | EP | claimed |
| EP-1483255-A1 | PROCESS FOR SYNTHESIZING CHIRAL N-ARYL PIPERAZINES | Wyeth, A Corporation of the State of Delaware (US) | 2004-12-08 | — | — | EP | claimed |
| US-20040230056-A1 | Process for synthesizing N-aryl piperazines with chiral N'-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | WYETH | 2004-11-18 | — | — | US | claimed |
| US-6756370-B1 | POTENT 5-HT2A RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2004-06-29 | — | — | US | claimed |
| US-6713626-B2 | Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | WYETH | 2004-03-30 | — | — | US | claimed |
| WO-2003078417-A1 | PROCESS FOR SYNTHESIZING CHIRAL N-ARYL PIPERAZINES | WYETH, A CORPORATION OF THE STATE OF DELAWARE (US) | 2003-09-25 | — | — | WO | claimed |
| WO-2003078420-A2 | PROCESS FOR MAKING CHIRAL 1,4-DISUBSTITUTED PIPERAZINES | WYETH (US) | 2003-09-25 | — | — | WO | claimed |
| US-6344458-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2002-02-05 | — | — | US | claimed |
| EP-1140838-A1 | 1, 4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | claimed |
| EP-1140882-A1 | PIPERAZINE ETHYLAMIDE DERIVATIVES WITH 5-HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | claimed |
| US-20010014680-A1 | 1,4-piperazine derivatives | WYETH | 2001-08-16 | — | — | US | claimed |
| US-6255302-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-07-03 | — | — | US | claimed |
| WO-2000035892-A1 | PIPERAZINE ETHYLAMIDE DERIVATIVES WITH 5-HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | claimed |
| WO-2000035878-A1 | 1,4-PIPERAZINE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | claimed |
| US-5693642-A | ANXIOLYTIC AND HYPOTENSIVE AGENTS; ANTIDEPRESSANTS; PSYCHOLOGICAL DISORDERS; CONTROLLERS OF SLEEP/WAKE CYCLE, EATING AND SEXUAL DISORDERS | JOHN WYETH & BROTHER LTD. (GB) | 1997-12-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040230056-A1 | Process for synthesizing N-aryl piperazines with chiral N'-1-[benzoyl(2-pyridyl)amino]-2-propane substitution | TPH1, HTR1B, HTR1A | ITGB2 1128/4885ICAM1 2829/4885ITGAL 1818/4885 |
| US-20010014680-A1 | 1,4-piperazine derivatives | ADH1A, ADH1C, SNCA | ITGB2 2245/4885ICAM1 899/4885ITGAL 3087/4885 |
| US-20050228181-A1 | Process for making chiral 1,4-disubstituted piperazines | HTR5A, HTR1A, HTR1D | ITGB2 2298/4885ICAM1 2401/4885ITGAL 2218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.