Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381589 | 0.98 | LMNA (0.49) | LMNASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL10642955 | 0.80 | ALDH1A1 (0.48) | LMNASMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL7379103 | 0.80 | GABRA1 (0.55) | MAPTALDH1A1POLBMEN1PKM | |
| SCHEMBL7383182 | 0.78 | GABRA1 (0.70) | LMNAMAPTALDH1A1POLBGABRA1 | |
| SCHEMBL10642534 | 0.77 | GABRP (0.58) | LMNASMN1; SMN2MAPTALDH1A1POLB | |
| SCHEMBL7381194 | 0.77 | GABRA1 (0.59) | LMNAMAPTALDH1A1POLBGABRA1 | |
| Hydrochloric Acid SCHEMBL10641678 | 0.76 | GABRP (0.57) | LMNASMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL5849419 | 0.76 | GABRA1 (0.68) | LMNASMN1; SMN2MAPTALDH1A1PKM | |
| SCHEMBL10708316 | 0.76 | GABRA1 (0.75) | LMNAMAPTALDH1A1POLBGABRA1 | |
| SCHEMBL10642399 | 0.76 | FBP1 (0.45) | LMNASMN1; SMN2MAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731358-A | β-carbolines and their use as tranquilizers | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-03-15 | — | — | US | disclosed |