Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654440 | 0.93 | MAPK1 (0.45) | MAPK1L3MBTL1TDP1ALDH1A1HTT | |
| SCHEMBL10873353 | 0.87 | ALDH1A1 (0.47) | MAPK1L3MBTL1TDP1ALDH1A1HTT | |
| SCHEMBL9620470 | 0.81 | ALDH1A1 (0.54) | MAPK1L3MBTL1ALDH1A1HTTMAPT | |
| SCHEMBL9811280 | 0.80 | ALDH1A1 (0.39) | MAPK1L3MBTL1TDP1ALDH1A1HTT | |
| SCHEMBL10652013 | 0.78 | VCAM1 (0.47) | L3MBTL1TDP1ALDH1A1MAPTTSHR | |
| SCHEMBL4815935 | 0.77 | TDP1 (0.54) | MAPK1L3MBTL1TDP1ALDH1A1MAPT | |
| SCHEMBL10656087 | 0.77 | KMT2A (0.50) | L3MBTL1TDP1ALDH1A1HTTMAPT | |
| SCHEMBL10653026 | 0.77 | TDP1 (0.45) | L3MBTL1TDP1ALDH1A1MAPTTSHR | |
| SCHEMBL10741160 | 0.72 | ALDH1A1 (0.43) | MAPK1L3MBTL1TDP1ALDH1A1HTT | |
| SCHEMBL2257980 | 0.70 | TDP1 (0.64) | MAPK1L3MBTL1TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0197386-B1 | 2-(SUBSTITUTED SULFAMYL) DERIVATIVES OF 6-NITROBENZOIC ACID, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1988-11-02 | — | — | EP | claimed |