Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | HTR1B | P28222 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 19/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067208 | 1.00 | CHRM2 (0.64) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL29387278 | 0.87 | CHRM2 (0.57) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL798695 | 0.86 | CHRM2 (0.67) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL774519 | 0.86 | CHRM2 (0.67) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL1697447 | 0.84 | CHRM2 (0.64) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL8875999 | 0.81 | HTR6 (0.53) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL6180265 | 0.81 | HTR6 (0.53) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL7079772 | 0.81 | HTR6 (0.53) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL773348 | 0.80 | HTR6 (0.54) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL774709 | 0.80 | HTR6 (0.54) | CHRM2HTR1AADRA2ACHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004811-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTSITUTED INDOLE DERIVATIVE | IND-SWIFT LABORATORIES LIMITED (IN) | 2012-01-12 | — | — | WO | disclosed |
| WO-2011004391-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ELETRIPTAN AND ITS SALT THEREOF | MATRIX LABORATORIES LTD (IN) | 2011-01-13 | — | — | WO | disclosed |
| US-20090299077-A1 | Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan | PLUS CHEMICALS SA (CH) | 2009-12-03 | — | — | US | disclosed |
| WO-2009142771-A2 | SALTS OF (R)-5-(2-PHENYLSULPHONYLETHENYL)-3-(N- METHYLPYRROLIDIN-2-YLMETHYL)-1H-INDOLE, 5-BROMO-3-[(R)-1- METHYL-PYRROLIDIN-2- YLMETHYL]-1H-INDOLE AND OF ELETRIPTAN | PLUS CHEMICALS, S.A. (CH) | 2009-11-26 | — | — | WO | disclosed |
| US-7288662-B2 | Process for the preparation of eletriptan | PFIZER, INC. (US) | 2007-10-30 | — | — | US | disclosed |
| EP-1373254-B1 | Process for the preparation of the anti-migraine drug eletriptan | PFIZER LTD (GB) | 2005-11-02 | — | — | EP | disclosed |
| US-20050059828-A1 | Process for the preparation of eletriptan | PFIZER INC. | 2005-03-17 | — | — | US | disclosed |
| US-20030166704-A1 | New process | PFIZER INC. | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059828-A1 | Process for the preparation of eletriptan | TFPI, HTR3A, HTR3E | CHRM2 1399/4885HTR1A 15/4885ADRA2A 2204/4885 |
| US-20030166704-A1 | New process | TFPI, HTR4, HTR5A | CHRM2 803/4885HTR1A 19/4885ADRA2A 2797/4885 |
| US-20090299077-A1 | Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan | TPH1, SUCNR1, TPSD1 | CHRM2 782/4885HTR1A 9/4885ADRA2A 1065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.