SCHEMBL1067804

SCHEMBL1067804

COc1cc(OC)nc(S)n1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.45
CYP1A2 P05177 1/20 0.43
ALDH1A1 P00352 4/20 0.41
KDM4E B2RXH2 3/20 0.41
PDE2A O00408 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
HPGD P15428 1/20 0.36
RECQL P46063 1/20 0.36
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
POLB P06746 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
XBP1 P17861 1/20 0.34
HTT P42858 1/20 0.34
PAX8 Q06710 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11752041 0.85 CYP1A2 (0.44) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL11583546 0.84 ALDH1A1 (0.39) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL21338291 0.79 GAA (0.49) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL14782540 0.77 LMNA (0.52) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL439716 0.74 LMNA (0.59) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL423183 0.74 PDE2A (0.61) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL401292 0.72 LMNA (0.54) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL4059265 0.72 LMNA (0.48) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL6386090 0.72 LMNA (0.48) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1
SCHEMBL8886934 0.72 LMNA (0.48) LMNASMN1; SMN2L3MBTL1CYP1A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118085765-A Adhesive film composition, packaging adhesive film, photovoltaic module and preparation method of photovoltaic module 天合光能股份有限公司 2024-05-28 CN claimed
CN-117327058-A Synthesis method of 7- [ (4, 6-dimethyl-2-pyrimidinyl) thio ] -3-methyl-1 (3H) -isopropyl furanone 顺毅南通化工有限公司 2024-01-02 CN claimed
CN-116675678-A Synthesis method of pyriftalid 顺毅南通化工有限公司 2023-09-01 CN claimed
CN-108841363-B Pure electric vehicle cooling liquid and preparation method and application thereof 深圳市百顺源节能科技有限公司 2020-10-16 CN claimed
CN-101514190-B Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis UNIV DONGHUA 2011-06-08 CN claimed
CN-101391984-B Method for carrying out methylation to pyrimidine heterocyclic compound containing sulfhydryl by dimethyl carbonate UNIV DONGHUA 2010-12-08 CN claimed
CN-101514190-A Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis UNIV DONGHUA (CN) 2009-08-26 CN claimed
CN-101391984-A Method for carrying out methylation to pyrimidine heterocyclic compound containing sulfhydryl by dimethyl carbonate UNIV DONGHUA (CN) 2009-03-25 CN claimed
EP-1165524-B1 METHOD OF PRODUCING THIOBARBITURIC ACID DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2005-06-01 EP claimed
WO-2000046212-A1 METHOD OF PRODUCING SUBSTITUTED PYRIMIDINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2000-08-10 WO claimed
CN-119330891-A Pyrithiobac-sodium intermediate compound, and preparation method and application thereof 烟台药物研究所 2025-01-21 CN disclosed
CN-118085765-A Adhesive film composition, packaging adhesive film, photovoltaic module and preparation method of photovoltaic module 天合光能股份有限公司 2024-05-28 CN disclosed
CN-117327058-A Synthesis method of 7- [ (4, 6-dimethyl-2-pyrimidinyl) thio ] -3-methyl-1 (3H) -isopropyl furanone 顺毅南通化工有限公司 2024-01-02 CN disclosed
CN-117327058-A Synthesis method of 7- [ (4, 6-dimethyl-2-pyrimidinyl) thio ] -3-methyl-1 (3H) -isopropyl furanone 顺毅南通化工有限公司 2024-01-02 CN disclosed
CN-116675678-A Synthesis method of pyriftalid 顺毅南通化工有限公司 2023-09-01 CN disclosed
US-4923501-A COTTON; NONPHYTOTOXIC KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1990-05-08 US disclosed
EP-0347811-A1 Alkanoic acid derivatives and herbicidal compositions KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1989-12-27 EP disclosed
EP-0315889-A2 Pyrimidine derivatives, processes for their production, and herbicidal method and compositions KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1989-05-17 EP disclosed
US-4057634-A Antiprotozoal(1-alkyl-5-nitro-imidazolyl-2-alkyl)-pyridazines HOECHST AKTIENGESELLSCHAFT (DT) 1977-11-08 US disclosed
US-3991191-A Antiprotozoal (1-alkyl-5-nitro-imidazolyl-2-alkyl)-pyrimidines HOECHST AKTIENGESELLSCHAFT (DT) 1976-11-09 US disclosed