Sugi Predict

Sugi Predict / Compounds / SCHEMBL401292

SCHEMBL401292

SCHEMBL401292

COc1cc(OC)nc([O])n1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.54
▸ SMN1; SMN2 Q16637 2/20 0.54
▸ CYP1A2 P05177 1/20 0.48
▸ ALDH1A1 P00352 2/20 0.46
▸ KDM4E B2RXH2 1/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.45
▸ TDP1 Q9NUW8 1/20 0.42
▸ PDE2A O00408 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ GAA P10253 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ XBP1 P17861 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ PAX8 Q06710 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27519654 0.85 SMN1; SMN2 (0.42) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL21830589 0.78 ALDH1A1 (0.52) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL14782540 0.77 LMNA (0.52) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL439716 0.74 LMNA (0.59) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL423183 0.74 PDE2A (0.61) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL401293 0.72 CYP1A2 (0.48) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL17622145 0.72 LMNA (0.48) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL4059265 0.72 LMNA (0.48) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL8886934 0.72 LMNA (0.48) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E
SCHEMBL8656719 0.72 LMNA (0.48) LMNASMN1; SMN2CYP1A2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100210467-A1 AGENT FOR IMPROVING SUGARCANE BRIX AND METHOD OF PROMOTING SUGARCANE RIPENING USING THE SAME KUMIAI CHEMICAL INDUSTRY CO., LTD. 2010-08-19 — — US claimed
EP-0507962-B1 PICOLINIC ACID DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO (JP) 2001-06-13 — — EP claimed
EP-0671880-A1 SELECTIVE HERBICIDAL COMPOSITION CIBA-GEIGY AG (CH) 1995-09-20 — — EP claimed
US-5391537-A Picolinic acid derivative, and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-02-21 — — US claimed
WO-1994000987-A2 SELECTIVE HERBICIDAL COMPOSITION CIBA-GEIGY AG (CH) 1994-01-20 — — WO claimed
EP-0507962-A1 PICOLINIC ACID DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1992-10-14 — — EP claimed
EP-3153023-B1 BENZOXAZOLE KINASE INHIBITORS AND METHODS OF USE TAKEDA PHARMACEUTICALS CO (JP) 2022-03-16 — — EP disclosed
US-20210253566-A1 CYTOCHROME P450 INHIBITORS AND USES THEREOF ANGION BIOMEDICA CORP. 2021-08-19 — — US disclosed
CN-112961149-A Cytochrome P450 inhibitors and uses thereof 安吉恩生物医药公司 2021-06-15 — — CN disclosed
US-20210171515-A1 CYTOCHROME P450 INHIBITORS AND USES THEREOF ANGION BIOMEDICA CORP. 2021-06-10 — — US disclosed
EP-3180335-B1 CYTOCHROME P450 INHIBITORS AND USES THEREOF ANGION BIOMEDICA CORP (US) 2021-05-05 — — EP disclosed
CN-107074841-B Cytochrome P450 inhibitors and uses thereof 安吉恩生物医药公司 2021-03-26 — — CN disclosed
US-10556893-B2 Cytochrome P450 inhibitors and uses thereof ANGION BIOMEDICA CORP. (US) 2020-02-11 — — US disclosed
US-5541148-A USED WITH AGRICULTURAL CEREAL CROPS CIBA-GEIGY CORPORATION (US) 1996-07-30 — — US disclosed
US-5527763-A HIGHLY SAFE TO CROP PLANTS KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1996-06-18 — — US disclosed
EP-0671880-A1 SELECTIVE HERBICIDAL COMPOSITION CIBA-GEIGY AG (CH) 1995-09-20 — — EP disclosed
US-5391537-A Picolinic acid derivative, and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-02-21 — — US disclosed
EP-0581960-A1 PYRIMIDINE OR TRIAZINE DERIVATIVE AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1994-02-09 — — EP disclosed
WO-1994000987-A2 SELECTIVE HERBICIDAL COMPOSITION CIBA-GEIGY AG (CH) 1994-01-20 — — WO disclosed
EP-0507962-A1 PICOLINIC ACID DERIVATIVE, PRODUCTION THEREOF, AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1992-10-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210171515-A1 CYTOCHROME P450 INHIBITORS AND USES THEREOF CYP7A1, CYP2E1, CYP11B1 LMNA 2070/4885SMN1; SMN2 3698/4885CYP1A2 4/4885
US-20210253566-A1 CYTOCHROME P450 INHIBITORS AND USES THEREOF CYP7A1, CYP2E1, CYP1A2 LMNA 2143/4885SMN1; SMN2 3732/4885CYP1A2 3/4885
US-10556893-B2 Cytochrome P450 inhibitors and uses thereof CYP7A1, CYP2E1, CYP1A2 LMNA 2143/4885SMN1; SMN2 3732/4885CYP1A2 3/4885
US-20100210467-A1 AGENT FOR IMPROVING SUGARCANE BRIX AND METHOD OF PROMOTING SUGARCANE RIPENING USING THE SAME BRIX1, MGAM, MGAM2 LMNA 3335/4885SMN1; SMN2 1337/4885CYP1A2 3682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.