Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.53 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834305 | 0.79 | CYSLTR1 (0.69) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL11899992 | 0.78 | PARP10 (0.48) | FFAR1 | |
| SCHEMBL10690 | 0.78 | CYSLTR1 (0.54) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL11898956 | 0.78 | ADAM17 (0.50) | FFAR1AKR1B1 | |
| SCHEMBL8890067 | 0.77 | CYSLTR1 (0.63) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL5796 | 0.77 | MAOB (0.46) | FFAR1 | |
| SCHEMBL8834948 | 0.77 | CYSLTR1 (0.62) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL22209124 | 0.77 | FFAR1 (0.80) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8902567 | 0.77 | ALOX5 (0.72) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL8834916 | 0.77 | FFAR1 (0.83) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | PFIZER INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-8853258-B2 | C-linked hydroxamic acid derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | BROWN MATTHEW FRANK (US) | 2012-08-09 | — | — | US | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | HAX1, LPXN, AGXT | FFAR1 1313/4885AKR1B1 1869/4885CYSLTR1 948/4885 |
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | LCT, AGXT, PRXL2A | FFAR1 2319/4885AKR1B1 3647/4885CYSLTR1 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.