Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.46 |
| ▸ | PYGM | P11217 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694512 | 0.85 | CACNA1S (0.51) | PYGLPYGMCYP19A1KMT2ATSHR | |
| SCHEMBL10695532 | 0.82 | TSHR (0.65) | PYGLPYGMCYP19A1KMT2ATSHR | |
| SCHEMBL30489285 | 0.82 | TSHR (0.65) | PYGLPYGMCYP19A1KMT2ATSHR | |
| SCHEMBL10694700 | 0.82 | DRD2 (0.39) | KMT2ATSHR | |
| SCHEMBL9147933 | 0.76 | LMNA (0.64) | LMNAGID4CYP19A1DDB1CRBN | |
| SCHEMBL10691415 | 0.75 | DRD2 (0.44) | CYP19A1KMT2AGAACHRNA7MEN1 | |
| SCHEMBL2003982 | 0.73 | DDB1 (0.59) | LMNAGID4CYP19A1DDB1CRBN | |
| SCHEMBL7673770 | 0.71 | ROCK2 (0.54) | GID4CYP19A1DDB1CRBNCHRNA7 | |
| SCHEMBL6286139 | 0.70 | CYP19A1 (0.55) | LMNAGID4CYP19A1DDB1CRBN | |
| SCHEMBL11618387 | 0.70 | SLC6A2 (0.58) | GID4CYP19A1DDB1CRBNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |