Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694704 | 0.80 | DRD2 (0.40) | DRD2DRD3HTR2CADRA2AADRA2B | |
| SCHEMBL10688450 | 0.80 | ADRA1A (0.46) | DRD2HTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL10694512 | 0.78 | CACNA1S (0.51) | CYP19A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10690626 | 0.77 | HTR1A (0.45) | DRD2HTR2AADRA1AALDH1A1KDM4E | |
| SCHEMBL30489285 | 0.76 | TSHR (0.65) | DRD2HTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL10695532 | 0.76 | TSHR (0.65) | DRD2HTR2CADRA2AADRA2BADRA2C | |
| SCHEMBL10368739 | 0.75 | HSD11B1 (0.45) | ALDH1A1L3MBTL1KDM4EUSP2GAA | |
| SCHEMBL10691585 | 0.75 | LMNA (0.49) | ALDH1A1KDM4EGAAHSD17B10CYP19A1 | |
| SCHEMBL13495369 | 0.72 | CYP19A1 (0.45) | ALDH1A1L3MBTL1USP2RECQLCYP19A1 | |
| SCHEMBL9560256 | 0.71 | MAPT (0.56) | DRD2HTR2CADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |