Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691585 | 0.82 | LMNA (0.49) | TSHRKMT2A | |
| SCHEMBL10694704 | 0.79 | DRD2 (0.40) | DRD2DRD4ADRA1DADRA1AADRA1B | |
| SCHEMBL30489285 | 0.75 | TSHR (0.65) | DRD2DRD4ADRA1DADRA1AADRA1B | |
| SCHEMBL10695532 | 0.75 | TSHR (0.65) | DRD2DRD4ADRA1DADRA1AADRA1B | |
| SCHEMBL10694512 | 0.70 | CACNA1S (0.51) | TSHRKMT2A | |
| SCHEMBL10692186 | 0.69 | BACE1 (0.35) | DRD2HTR1AGRIN1 | |
| SCHEMBL6281661 | 0.69 | CACNA1S (0.53) | DRD2DRD4 | |
| SCHEMBL6280175 | 0.69 | HTR7 (0.37) | DRD2DRD4TSHRHTR1A | |
| SCHEMBL10693674 | 0.66 | BACE1 (0.35) | DRD2TSHRGRIN1 | |
| SCHEMBL27950450 | 0.65 | PRSS1 (0.53) | TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |