Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10693883 | 0.88 | BACE1 (0.44) | BACE1BACE2ARSCN9AMEN1 | |
| SCHEMBL10695891 | 0.84 | OPRD1 (0.41) | AR | |
| SCHEMBL10695992 | 0.79 | SCN9A (0.39) | ARSCN9AALDH1A1MAPT | |
| SCHEMBL10692622 | 0.78 | CNR1 (0.39) | BACE1AR | |
| SCHEMBL7679980 | 0.77 | BACE1 (0.45) | BACE1BACE2ARKMT2ASIGMAR1 | |
| SCHEMBL10694802 | 0.76 | BACE1 (0.44) | BACE1BACE2SCN9AALDH1A1MAPT | |
| SCHEMBL7677681 | 0.76 | OPRM1 (0.44) | BACE1BACE2ARMEN1KMT2A | |
| SCHEMBL10692682 | 0.74 | NPC1 (0.47) | BACE1ARUSP2ALDH1A1MAPT | |
| SCHEMBL622589 | 0.73 | PDE4A (0.46) | BACE1BACE2ARSCN9AMEN1 | |
| SCHEMBL10694576 | 0.69 | POLB (0.33) | BACE1ALDH1A1MAPTHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |