Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 13/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692622 | 0.87 | CNR1 (0.39) | NR3C1ARESR2 | |
| SCHEMBL10692592 | 0.84 | BACE1 (0.44) | AR | |
| SCHEMBL10692682 | 0.80 | NPC1 (0.47) | NR3C1AR | |
| SCHEMBL10693883 | 0.78 | BACE1 (0.44) | NR3C1AR | |
| SCHEMBL10693819 | 0.75 | OPRD1 (0.40) | OPRD1OPRM1OPRK1 | |
| SCHEMBL10695992 | 0.74 | SCN9A (0.39) | AR | |
| SCHEMBL10694392 | 0.69 | NPC1 (0.47) | OPRM1OPRK1 | |
| SCHEMBL20714380 | 0.69 | L3MBTL1 (0.41) | OPRM1 | |
| SCHEMBL10694576 | 0.68 | POLB (0.33) | — | |
| SCHEMBL980926 | 0.65 | SLC6A2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |