Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691593 | 0.87 | L3MBTL1 (0.42) | BACE1BACE2KMT2AMAPTTSHR | |
| SCHEMBL10693674 | 0.84 | BACE1 (0.35) | BACE1BACE2TSHRALDH1A1 | |
| SCHEMBL10693819 | 0.83 | OPRD1 (0.40) | SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL10691597 | 0.77 | ADRA1A (0.39) | MAPTTSHRSCN9AALDH1A1 | |
| SCHEMBL10691351 | 0.77 | GPR55 (0.39) | KMT2AMAPTTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL10692592 | 0.76 | BACE1 (0.44) | BACE1BACE2SIGMAR1PRMT5WDR77 | |
| SCHEMBL10692789 | 0.73 | BACE1 (0.37) | BACE1BACE2MAPTTSHRALDH1A1 | |
| SCHEMBL10695401 | 0.72 | RAD52 (0.42) | BACE1MAPTTSHRALDH1A1OPRM1 | |
| SCHEMBL10694665 | 0.67 | RAD52 (0.36) | MAPTTSHRALDH1A1OPRM1OPRK1 | |
| SCHEMBL10696619 | 0.65 | RAD52 (0.34) | MAPTALDH1A1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |