Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 7/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691351 | 0.86 | GPR55 (0.39) | EHMT2RAD52 | |
| SCHEMBL10694802 | 0.83 | BACE1 (0.44) | OPRD1SIGMAR1OPRK1OPRM1 | |
| SCHEMBL10695401 | 0.79 | RAD52 (0.42) | EHMT2OPRK1RAD52OPRM1 | |
| SCHEMBL10693674 | 0.77 | BACE1 (0.35) | — | |
| SCHEMBL10691593 | 0.77 | L3MBTL1 (0.42) | — | |
| SCHEMBL10695891 | 0.75 | OPRD1 (0.41) | OPRD1OPRK1OPRM1 | |
| SCHEMBL10691597 | 0.72 | ADRA1A (0.39) | RAD52 | |
| SCHEMBL10692789 | 0.71 | BACE1 (0.37) | EHMT2 | |
| SCHEMBL2470209 | 0.66 | NOTUM (0.46) | EHMT2RAD52 | |
| SCHEMBL10694665 | 0.66 | RAD52 (0.36) | EHMT2OPRK1RAD52OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |