Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.61 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259739 | 0.91 | ACHE (0.72) | ACHETP53SMN1; SMN2MAPTKMT2A | |
| SCHEMBL9253566 | 0.86 | ACHE (0.64) | ACHEKMT2AMEN1CYP1A2TSHR | |
| SCHEMBL9253474 | 0.86 | MEN1 (0.71) | ACHETP53SMN1; SMN2MAPTKMT2A | |
| SCHEMBL9257692 | 0.82 | ACHE (0.72) | ACHESOS1TP53SMN1; SMN2MAPT | |
| SCHEMBL9252906 | 0.81 | ACHE (0.60) | ACHESOS1TP53SMN1; SMN2MAPT | |
| SCHEMBL18038492 | 0.81 | ACHE (0.63) | ACHESOS1TP53SMN1; SMN2MAPT | |
| SCHEMBL9252701 | 0.80 | MAPT (0.63) | ACHEMAPTPOLBGAATSHR | |
| SCHEMBL9258030 | 0.79 | ACHE (0.68) | ACHECYP1A2TSHRBCHE | |
| SCHEMBL9250740 | 0.78 | ACHE (0.53) | ACHETP53MAPTPOLBGAA | |
| SCHEMBL9256916 | 0.77 | ACHE (0.75) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282959-A2 | Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-09-21 | — | — | EP | disclosed |