Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10719098 | 0.86 | MAPT (0.54) | MAPTPKMPTGS2KDM4ERXFP1 | |
| SCHEMBL10730881 | 0.84 | MAPT (0.54) | MAPTPKMPTGS2KDM4EALDH1A1 | |
| SCHEMBL10726134 | 0.79 | MAPT (0.49) | MAPTPKMKDM4EALDH1A1NPC1 | |
| SCHEMBL10730384 | 0.79 | MAPT (0.56) | MAPTKDM4EALDH1A1NPC1KMT2A | |
| SCHEMBL10716650 | 0.79 | MAPT (0.78) | MAPTPKMALDH1A1NPC1LMNA | |
| SCHEMBL10716454 | 0.77 | POLB (0.50) | MAPTKDM4ENPSR1ALDH1A1NPC1 | |
| SCHEMBL10716446 | 0.77 | MAPT (0.50) | MAPTPKMPTGS2KDM4EALDH1A1 | |
| SCHEMBL10716583 | 0.77 | MAPT (0.56) | MAPTPKMPTGS2KDM4EALDH1A1 | |
| SCHEMBL10730963 | 0.75 | MAPT (0.45) | MAPTPKMPTGS2KDM4EALDH1A1 | |
| SCHEMBL10718982 | 0.75 | MAPT (0.48) | MAPTPKMALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |