Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716377 | 0.79 | MAPT (0.56) | MAPTMAPK1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10730725 | 0.79 | MAPT (0.48) | MAPTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL10718982 | 0.77 | MAPT (0.48) | MAPTMAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL10730881 | 0.77 | MAPT (0.54) | MAPTCYP1A2CYP3A4CYP2C19NPC1 | |
| SCHEMBL10726134 | 0.75 | MAPT (0.49) | MAPTNPC1RAB9AHTTATM | |
| SCHEMBL10726355 | 0.74 | MAPT (0.55) | MAPTNPC1KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL10730781 | 0.74 | MAPT (0.58) | MAPTNPC1RAB9AHTTKDM4E | |
| SCHEMBL10716650 | 0.72 | MAPT (0.78) | MAPTNPC1HTTKMT2AALDH1A1 | |
| SCHEMBL10717891 | 0.72 | MAPT (1.00) | MAPTNPC1HTTL3MBTL1KMT2A | |
| SCHEMBL10730963 | 0.71 | MAPT (0.45) | MAPTCYP1A2CYP3A4CYP2C19ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4647569-A | Antiarthritic pyridylaminoethene disulfonyl compounds and use | MAY & BAKER LIMITED (GB) | 1987-03-03 | — | — | US | claimed |
| US-4647569-A | Antiarthritic pyridylaminoethene disulfonyl compounds and use | MAY & BAKER LIMITED (GB) | 1987-03-03 | — | — | US | disclosed |