Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA4 | P22748 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10717698 | 0.88 | MAPT (0.72) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL10717891 | 0.88 | MAPT (1.00) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL10719158 | 0.84 | MAPT (0.71) | MAPTPKMALDH1A1NPC1MEN1 | |
| SCHEMBL10716463 | 0.82 | MAPT (0.64) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL10716583 | 0.79 | MAPT (0.56) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL10716377 | 0.79 | MAPT (0.56) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL11787040 | 0.78 | MAPT (0.56) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL11457925 | 0.78 | CA2 (0.57) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL11457926 | 0.78 | CA2 (0.57) | MAPTPKMALDH1A1NPC1CA2 | |
| SCHEMBL10717722 | 0.76 | MAPT (0.53) | MAPTPKMALDH1A1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |