Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CNR2 | P34972 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716650 | 0.76 | MAPT (0.78) | MAPTALDH1A1LMNAHTTNPC1 | |
| SCHEMBL1413883 | 0.75 | ALPL (0.79) | MAPTCNR2ALDH1A1KDM4EALPL | |
| SCHEMBL10716646 | 0.74 | MAPT (0.50) | MAPTKDM4ERAB9ANPC1SMN1; SMN2 | |
| SCHEMBL212127 | 0.74 | KDR (0.54) | MAPTKDRACP1ALDH1A1KDM4E | |
| SCHEMBL28134632 | 0.72 | KDR (0.53) | MAPTKDRACP1ALDH1A1KDM4E | |
| SCHEMBL10726778 | 0.72 | MAPT (0.51) | MAPTALPLKMT2APKM | |
| SCHEMBL10296114 | 0.72 | MGAM (0.51) | CNR2KDRACP1ALDH1A1KDM4E | |
| SCHEMBL10716583 | 0.71 | MAPT (0.56) | MAPTALDH1A1KDM4ELMNAHTT | |
| SCHEMBL10716377 | 0.71 | MAPT (0.56) | MAPTALDH1A1KDM4ELMNAMAPK1 | |
| SCHEMBL10716463 | 0.71 | MAPT (0.64) | MAPTALDH1A1LMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |