Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA4 | P22748 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | ALPL | P05186 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716578 | 0.76 | PKM (0.49) | MAPTPKM | |
| SCHEMBL10716650 | 0.74 | MAPT (0.78) | MAPTCA2CA1CA4CA9 | |
| SCHEMBL10717722 | 0.72 | MAPT (0.53) | MAPTALPLKMT2APKM | |
| SCHEMBL10716620 | 0.71 | MAPT (0.46) | MAPTCA2CA1CA4CA9 | |
| SCHEMBL10716463 | 0.69 | MAPT (0.64) | MAPTCA2CA1CA4CA9 | |
| SCHEMBL10717891 | 0.68 | MAPT (1.00) | MAPTCA2CA1CA4CA9 | |
| SCHEMBL10717698 | 0.68 | MAPT (0.72) | MAPTCA2CA1CA4CA9 | |
| SCHEMBL10726333 | 0.68 | PKM (0.48) | MAPTCA2CA1CA4CA9 | |
| SCHEMBL28284703 | 0.67 | SIRT2 (0.51) | SIRT2SIRT1SIRT3ALPLMEN1 | |
| SCHEMBL10716446 | 0.67 | MAPT (0.50) | MAPTPTGS2MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4647569-A | Antiarthritic pyridylaminoethene disulfonyl compounds and use | MAY & BAKER LIMITED (GB) | 1987-03-03 | — | — | US | claimed |
| US-4647569-A | Antiarthritic pyridylaminoethene disulfonyl compounds and use | MAY & BAKER LIMITED (GB) | 1987-03-03 | — | — | US | disclosed |