Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716583 | 0.83 | MAPT (0.56) | MAPTNPC1RAB9AKDM4EKMT2A | |
| SCHEMBL10730622 | 0.77 | MAPT (0.57) | MAPTNPC1RAB9AKDM4EKMT2A | |
| SCHEMBL10730881 | 0.75 | MAPT (0.54) | MAPTNPC1RAB9AKDM4EPKM | |
| SCHEMBL10717722 | 0.74 | MAPT (0.53) | MAPTNPC1RAB9AKDM4EKMT2A | |
| SCHEMBL10726719 | 0.73 | PKM (0.52) | MAPTNPC1RAB9APKM | |
| SCHEMBL10717754 | 0.73 | ALDH1A1 (0.52) | MAPTNPC1RAB9AKMT2APKM | |
| SCHEMBL10726196 | 0.73 | PKM (0.52) | MAPTPKMSMN1; SMN2 | |
| SCHEMBL10728354 | 0.73 | MAPT (0.46) | MAPTKDM4EHSD11B1PKMSMN1; SMN2 | |
| SCHEMBL10725434 | 0.73 | MAPT (0.49) | MAPTNPC1RAB9AKDM4EKMT2A | |
| SCHEMBL10716650 | 0.73 | MAPT (0.78) | MAPTNPC1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |