Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10730622 | 0.81 | MAPT (0.57) | MAPTHSD11B1ALDH1A1LMNAKDM4E | |
| SCHEMBL10716583 | 0.78 | MAPT (0.56) | MAPTALDH1A1LMNAPKMKDM4E | |
| SCHEMBL10730781 | 0.76 | MAPT (0.58) | MAPTPOLBALDH1A1LMNAPKM | |
| SCHEMBL1381858 | 0.74 | PDE4A (0.73) | PDE4AAGO2POLBGAAHSD11B1 | |
| SCHEMBL10726335 | 0.74 | CYP1A2 (0.44) | MAPTPOLBGAAHSD11B1ALDH1A1 | |
| SCHEMBL10730881 | 0.73 | MAPT (0.54) | MAPTPOLBALDH1A1LMNAPKM | |
| SCHEMBL10716646 | 0.72 | MAPT (0.50) | MAPTHSD11B1PKMKDM4EKMT2A | |
| SCHEMBL10725434 | 0.71 | MAPT (0.49) | MAPTALDH1A1LMNAPKMKDM4E | |
| SCHEMBL10716650 | 0.71 | MAPT (0.78) | MAPTALDH1A1LMNAPKMMEN1 | |
| SCHEMBL10717891 | 0.71 | MAPT (1.00) | MAPTGAAALDH1A1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4659727-A | ANTIARTHRITIC AGENTS | MAY & BAKER LIMITED (GB) | 1987-04-21 | — | — | US | disclosed |
| EP-0174832-A2 | Ethene derivatives | MAY & BAKER LIMITED (GB) | 1986-03-19 | — | — | EP | disclosed |