Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15743490 | 0.98 | CXCR4 (0.53) | CXCR4L3MBTL1PAOXHRH2HRH1 | |
| SCHEMBL613914 | 0.94 | L3MBTL1 (0.50) | CXCR4L3MBTL1HRH2HRH1LMNA | |
| SCHEMBL28716335 | 0.92 | L3MBTL1 (0.48) | CXCR4L3MBTL1HRH2HRH1LMNA | |
| SCHEMBL28706410 | 0.92 | L3MBTL1 (0.48) | CXCR4L3MBTL1HRH2HRH1LMNA | |
| SCHEMBL8859810 | 0.89 | L3MBTL1 (0.46) | CXCR4L3MBTL1HRH2HRH1LMNA | |
| SCHEMBL9978559 | 0.88 | FAAH (0.49) | CXCR4L3MBTL1PAOXHRH2HRH1 | |
| SCHEMBL1900720 | 0.88 | L3MBTL1 (0.63) | CXCR4L3MBTL1HRH2HRH1KDM4E | |
| Hydrochloric Acid SCHEMBL8742997 | 0.86 | L3MBTL1 (0.61) | CXCR4L3MBTL1KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL27793739 | 0.84 | CYP1A2 (0.57) | CXCR4PAOXHRH2HRH1LMNA | |
| SCHEMBL5865021 | 0.84 | CYP1A2 (0.57) | CXCR4PAOXHRH2HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116171272-A | Novel VDAC1 inhibitors | 阿巴尔塞奥制药公司 | 2023-05-26 | — | — | CN | disclosed |
| US-9828352-B2 | Phenyl carbamates and their use as inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR) | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2017-11-28 | — | — | US | disclosed |
| EP-3022179-B1 | PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) | FOND ST ITALIANO TECNOLOGIA (IT) | 2017-11-15 | — | — | EP | disclosed |
| US-20160194296-A1 | PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-07-07 | — | — | US | disclosed |
| EP-3022179-A1 | PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) | Fondazione Istituto Italiano Di Tecnologia (IT) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015007615-A1 | PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2015-01-22 | — | — | WO | disclosed |
| US-20110085978-A1 | NOVEL QUINOLINYLAMIDE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2011-04-14 | — | — | US | disclosed |
| EP-2081907-B1 | ARYL PIPERAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | UNIV SIENA (IT) | 2011-01-26 | — | — | EP | disclosed |
| EP-2257531-A1 | NOVEL QUINOLINYLAMIDE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NeuroSearch A/S (DK) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009112568-A1 | NOVEL QUINOLINYLAMIDE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | NEUROSEARCH A/S (DK) | 2009-09-17 | — | — | WO | disclosed |
| US-20040116692-A1 | Reductive alkylation of saturated cyclic amines | MERCK SHARP & DOHME CORP. | 2004-06-17 | — | — | US | disclosed |
| US-6649761-B2 | Viricides such as 4-(1-(5-(5-methoxy-3-pyridinyl)-carbonyl-methylaminocarbonyl)-1-methylethyl)-2(S)-((2,2,2-trifluoro-ethyl)aminocarbonyl)-1-(allyloxycarbonyl)piperazine and salts formed by decarboxylation using acids, then purifying | MERCK & CO., INC. | 2003-11-18 | — | — | US | disclosed |
| US-6649761-B2 | Viricides such as 4-(1-(5-(5-methoxy-3-pyridinyl)-carbonyl-methylaminocarbonyl)-1-methylethyl)-2(S)-((2,2,2-trifluoro-ethyl)aminocarbonyl)-1-(allyloxycarbonyl)piperazine and salts formed by decarboxylation using acids, then purifying | MERCK & CO., INC. | 2003-11-18 | — | — | US | disclosed |
| US-6649761-B2 | Viricides such as 4-(1-(5-(5-methoxy-3-pyridinyl)-carbonyl-methylaminocarbonyl)-1-methylethyl)-2(S)-((2,2,2-trifluoro-ethyl)aminocarbonyl)-1-(allyloxycarbonyl)piperazine and salts formed by decarboxylation using acids, then purifying | MERCK & CO., INC. | 2003-11-18 | — | — | US | disclosed |
| US-20030144512-A1 | Process for preparing piperazinepentaneamide HIV protease inhibitors | MERCK & CO., INC. | 2003-07-31 | — | — | US | disclosed |
| US-20030144512-A1 | Process for preparing piperazinepentaneamide HIV protease inhibitors | MERCK & CO., INC. | 2003-07-31 | — | — | US | disclosed |
| US-20030144512-A1 | Process for preparing piperazinepentaneamide HIV protease inhibitors | MERCK & CO., INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2002096359-A2 | PIPERAZINE PENTANAMIDE HIV PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| EP-0773929-A1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996039386-A1 | PIPERIDINE DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110085978-A1 | NOVEL QUINOLINYLAMIDE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE AND SEROTONIN RECEPTORS | HTR3A, HTR2A, HTR1A | CXCR4 2664/4885L3MBTL1 1915/4885PAOX 3047/4885 |
| US-20160194296-A1 | PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) | FAAH, FAAH2, FFAR3 | CXCR4 1253/4885L3MBTL1 1662/4885PAOX 729/4885 |
| US-20030144512-A1 | Process for preparing piperazinepentaneamide HIV protease inhibitors | NPEPPS, PREP, DNPEP | CXCR4 3223/4885L3MBTL1 4377/4885PAOX 3012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.