Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A1 | P13866 | 1/20 | 0.44 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.44 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.42 |
| ▸ | SYNJ2 | O15056 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10791387 | 1.00 | SLC5A1 (0.44) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10790693 | 1.00 | SLC5A1 (0.44) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10787142 | 0.99 | SLC5A1 (0.43) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10787955 | 0.99 | SLC5A1 (0.43) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10787455 | 0.88 | SLC5A1 (0.46) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10790825 | 0.88 | SLC5A1 (0.46) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10791277 | 0.88 | SLC5A1 (0.46) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10788242 | 0.86 | SLC5A1 (0.44) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10773805 | 0.86 | SLC5A1 (0.44) | SLC5A1SLC5A2SLC28A3SYNJ2KDM4E | |
| SCHEMBL10790249 | 0.86 | POLB (0.48) | SLC5A1SLC5A2SLC28A3KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4708950-A | ANTILIPEMIC AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-11-24 | — | — | US | claimed |
| US-4450156-A | ANTITUMOR, ANTIINFLAMMATORY, ANTILIPEMIC, ANTIPYRETIC, HYPOGLYCEMIC AND HYPOTENSIVE AGENTS; ANALGESICS, DEPRESSANTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1984-05-22 | — | — | US | claimed |
| US-4322409-A | HYPOTENSIVE, HYPOGLYCEMIC, ANTITUMOR, ANTILIPEMIC AND ANTIINFLAMMATORY AGENTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1982-03-30 | — | — | US | claimed |
| US-4708950-A | ANTILIPEMIC AGENTS, ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-11-24 | — | — | US | disclosed |
| US-4450156-A | ANTITUMOR, ANTIINFLAMMATORY, ANTILIPEMIC, ANTIPYRETIC, HYPOGLYCEMIC AND HYPOTENSIVE AGENTS; ANALGESICS, DEPRESSANTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1984-05-22 | — | — | US | disclosed |
| US-4322409-A | HYPOTENSIVE, HYPOGLYCEMIC, ANTITUMOR, ANTILIPEMIC AND ANTIINFLAMMATORY AGENTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1982-03-30 | — | — | US | disclosed |