Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10818075 | 0.82 | RXRA (0.39) | NPBWR1KMT2APOLB | |
| SCHEMBL10811050 | 0.75 | EGLN1 (0.43) | HTTKMT2AMEN1LMNAMAPT | |
| SCHEMBL10813104 | 0.72 | P2RX7 (0.37) | KMT2AMEN1LMNAMAPTHPGD | |
| SCHEMBL10736444 | 0.72 | PTPN7 (0.43) | HTTKMT2AMEN1POLBLMNA | |
| SCHEMBL10738824 | 0.72 | RAB9A (0.43) | HTTKMT2AMEN1POLBLMNA | |
| SCHEMBL11021894 | 0.71 | ALKBH1 (0.41) | KMT2AMEN1CYP2D6MAPTCYP2C19 | |
| SCHEMBL10817552 | 0.71 | EGLN1 (0.47) | NPBWR1LMNACYP1A2MAPTCYP2C19 | |
| SCHEMBL4850585 | 0.68 | CYP1A2 (0.56) | HSP90AB1CNR1CNR2KMT2AMEN1 | |
| SCHEMBL31012122 | 0.68 | CYP1A2 (0.56) | HSP90AB1CNR1CNR2KMT2AMEN1 | |
| SCHEMBL11170879 | 0.67 | HPGD (0.47) | HTTCTRCLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087326-B1 | SUBSTITUTED PYRIMIDIN-2-ONES AND THE SALTS THEREOF | NYCOMED AS (NO) | 1987-05-13 | — | — | EP | disclosed |
| EP-0160573-A2 | Pyrimidinone derivatives | NYCOMED AS (NO) | 1985-11-06 | — | — | EP | disclosed |
| US-4539324-A | ANTICANCER AGENTS | NYEGAARD & CO. A/S (NO) | 1985-09-03 | — | — | US | disclosed |
| EP-0087326-A1 | Substituted pyrimidin-2-ones and the salts thereof | NYCOMED AS (NO) | 1983-08-31 | — | — | EP | disclosed |