Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815798 | 0.82 | HTT (0.39) | NPBWR1POLBKMT2A | |
| SCHEMBL11018085 | 0.79 | RXRA (0.41) | RXRAGRIN1GRIN2BSMN1; SMN2NPBWR1 | |
| SCHEMBL10813104 | 0.77 | P2RX7 (0.37) | P2RX7KMT2A | |
| SCHEMBL10811050 | 0.77 | EGLN1 (0.43) | RXRAGRIN1GRIN2BP2RX7SMN1; SMN2 | |
| SCHEMBL10812261 | 0.75 | MEN1 (0.34) | THRBKMT2A | |
| SCHEMBL10738824 | 0.74 | RAB9A (0.43) | NOTUMSMN1; SMN2POLBKMT2A | |
| SCHEMBL11021894 | 0.73 | ALKBH1 (0.41) | SMN1; SMN2MAOBKMT2A | |
| SCHEMBL10740627 | 0.71 | ALDH1A1 (0.39) | RXRAGRIN1GRIN2BSMN1; SMN2NPBWR1 | |
| SCHEMBL10817552 | 0.70 | EGLN1 (0.47) | SMN1; SMN2NPBWR1MAOB | |
| SCHEMBL10737268 | 0.69 | RAB9A (0.42) | SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087326-B1 | SUBSTITUTED PYRIMIDIN-2-ONES AND THE SALTS THEREOF | NYCOMED AS (NO) | 1987-05-13 | — | — | EP | disclosed |
| US-4539324-A | ANTICANCER AGENTS | NYEGAARD & CO. A/S (NO) | 1985-09-03 | — | — | US | disclosed |
| EP-0087326-A1 | Substituted pyrimidin-2-ones and the salts thereof | NYCOMED AS (NO) | 1983-08-31 | — | — | EP | disclosed |