Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10837065 | 0.83 | HTR1A (0.61) | SMN1; SMN2LMNAHTTTSHRCRBN | |
| SCHEMBL11764940 | 0.75 | CRBN (0.50) | CRBNMAPTHTR1AHTR2ADRD4 | |
| SCHEMBL2021859 | 0.72 | LMNA (0.70) | SMN1; SMN2LMNAHTTTSHRALDH1A1 | |
| SCHEMBL2021862 | 0.72 | LMNA (0.70) | SMN1; SMN2LMNAHTTTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL10838441 | 0.72 | HTR1A (0.65) | HTTALDH1A1MAPTDRD2HTR1A | |
| SCHEMBL10837822 | 0.70 | LMNA (0.58) | SMN1; SMN2LMNAHTTTSHRCRBN | |
| SCHEMBL10837830 | 0.70 | LMNA (0.58) | SMN1; SMN2LMNAHTTTSHRCRBN | |
| SCHEMBL7322501 | 0.70 | NR3C1 (0.69) | SMN1; SMN2LMNATSHRCRBNKDM4E | |
| Hydrochloric Acid SCHEMBL10838709 | 0.70 | HTR1A (0.69) | CRBNMAPTDRD2HTR1AHTR2A | |
| SCHEMBL23097745 | 0.69 | DRD2 (0.82) | MAPTDRD2HTR1AHTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |