SCHEMBL108929

SCHEMBL108929

CC(=O)Nc1ccc(N=Nc2cc(C)ccc2O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 1.00
AMY1A P0DUB6 8/20 0.64
MAPT P10636 6/20 0.60
NPC1 O15118 5/20 0.60
RAB9A P51151 5/20 0.60
LMNA P02545 1/20 0.60
HPGD P15428 1/20 0.60
NFKB1 P19838 1/20 0.60
NFKB2 Q00653 1/20 0.60
RELA Q04206 1/20 0.60
FTO Q9C0B1 1/20 0.59
MAPK1 P28482 2/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.56
TDP1 Q9NUW8 2/20 0.53
MEN1 O00255 3/20 0.49
GAA P10253 3/20 0.49
KMT2A Q03164 3/20 0.49
ALDH1A1 P00352 2/20 0.49
POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29374972 1.00 THRB (1.00) THRBAMY1AMAPTNPC1RAB9A
SCHEMBL108928 1.00 THRB (1.00) THRBAMY1AMAPTNPC1RAB9A
SCHEMBL12620630 0.83 TDP1 (0.77) THRBMAPTNPC1RAB9ALMNA
SCHEMBL4199168 0.83 TDP1 (0.77) THRBMAPTNPC1RAB9ALMNA
SCHEMBL18405965 0.83 TDP1 (0.77) THRBMAPTNPC1RAB9ALMNA
SCHEMBL3670865 0.82 THRB (0.70) THRBAMY1AMAPTNPC1RAB9A
SCHEMBL10811708 0.82 THRB (0.69) THRBAMY1AMAPTNPC1RAB9A
SCHEMBL10811704 0.82 THRB (0.69) THRBAMY1AMAPTNPC1RAB9A
SCHEMBL218723 0.81 THRB (0.68) THRBAMY1AMAPTNPC1RAB9A
SCHEMBL23511143 0.81 FTO (0.79) THRBMAPTNPC1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 260 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0992832-A1 Optical element for use in eye-protecting devices INTERCAST EUROPE S.P.A. (IT) 2000-04-12 EP claimed
US-5975695-A Optical element for use in eye-protecting devices INTERCAST EUROPE S.P.A. (IT) 1999-11-02 US claimed
US-4199317-A Printing process SUBLISTATIC HOLDING SA (CH) 1980-04-22 US claimed
JP-60030393-A None JP disclosed
US-20210115489-A1 NOVEL MEDIATOR KIKKOMAN CORPORATION (JP) 2021-04-22 US disclosed
EP-2263642-B1 Colouring bleaches HENKEL AG & CO KGAA (DE) 2020-04-15 EP disclosed
WO-2020039020-A1 BLUE LIGHT FILTER LENS DSM IP ASSETS B.V. (NL) 2020-02-27 WO disclosed
US-10557231-B2 Method for coloring cellulose Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) 2020-02-11 US disclosed
US-10451595-B2 Indicating devices based on lateral diffusion of a mobile phase through a non-porous stationary phase JP LABORATORIES, INC (US) 2019-10-22 US disclosed
EP-2930126-B1 Fashionable aerosol dye HENKEL AG & CO KGAA (DE) 2019-10-09 EP disclosed
EP-2797577-B1 COMPOSITIONS FOR DYEING KERATIN FIBERS HENKEL AG & CO KGAA (DE) 2018-06-13 EP disclosed
EP-0680996-A1 Benzoxazolyl optical brighteners in and for thermoplastic compositions GENERAL ELECTRIC COMPANY (US) 1995-11-08 EP disclosed
US-5364412-A Process for producing dyed laminated products FURUKAWA KENICHI (JP) 1994-11-15 US disclosed
JP-S6030393-A MONO-AZO COLORING MATTER FOR THERMAL TRANSFER RECORDING MITSUBISHI CHEM IND LTD 1985-02-15 JP disclosed
US-4395263-A Unitary laminate with permanent indicia pattern: transfer printings onto plastic-coated rigid panels DAVIS,DOUGLAS ROY 1983-07-26 US disclosed
US-4391893-A Magnetic developers and process for their preparation SUBLISTATIC HOLDING, S.A. (CH) 1983-07-05 US disclosed
US-4246331-A MONOAZO DYES OF ANTHRAQUINONE DYES SUBLISTATIC HOLDING SA (CH) 1981-01-20 US disclosed
US-4199317-A Printing process SUBLISTATIC HOLDING SA (CH) 1980-04-22 US disclosed
US-4145300-A DEVELOPERS CONTAINING MAGNETIC PARTICLES AND A SUBLIMABLE DYESTUFF SUBLISTATIC HOLDING S.A. (CH) 1979-03-20 US disclosed
US-3972904-A AMIDOSULFONATES HOECHST AKTIENGESELLSCHAFT (DT) 1976-08-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210115489-A1 NOVEL MEDIATOR MPO, EPX, LPO THRB 4364/4885AMY1A 1042/4885MAPT 4015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.