Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913839 | 0.86 | HRH2 (0.40) | KMT2AMEN1NPC1RAB9AHRH2 | |
| SCHEMBL10911579 | 0.86 | ALDH1A1 (0.39) | KMT2AMEN1NPC1RAB9AHRH2 | |
| SCHEMBL10911009 | 0.83 | TDP1 (0.39) | NPC1RAB9AHRH2HRH1ALDH1A1 | |
| SCHEMBL10913633 | 0.83 | LMNA (0.40) | NPC1RAB9AHRH2HRH1ALDH1A1 | |
| SCHEMBL10914333 | 0.82 | ACHE (0.39) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL10744810 | 0.81 | LDHA (0.39) | KMT2AMEN1NPC1RAB9AHRH2 | |
| SCHEMBL10913091 | 0.80 | MAPT (0.43) | KMT2AMEN1NPC1RAB9AHRH2 | |
| SCHEMBL10914742 | 0.78 | HRH2 (0.34) | KMT2AMEN1HRH2HRH1ALDH1A1 | |
| SCHEMBL6959645 | 0.76 | ALDH1A1 (0.44) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL10914201 | 0.74 | ACHE (0.39) | KMT2AMEN1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088940-B1 | PYRIDINE-CARBOXYLIC-ACID ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BAYER AG (DE) | 1986-05-21 | — | — | EP | disclosed |
| EP-0088938-B1 | USE OF PYRIDINE COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS WITH AN ANTIHYPOXEMIA AND ISCHEMIA-PROTECTIVE ACTIVITY | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088938-A1 | Use of pyridine compounds for the manufacture of medicaments with an antihypoxemia and ischemia-protective activity | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |
| EP-0088940-A1 | Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |