Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10922313 | 0.83 | MEN1 (0.51) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL11189411 | 0.78 | MEN1 (0.57) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL10921910 | 0.77 | MEN1 (0.56) | LMNAALDH1A1MAPTSMN1; SMN2TP53 | |
| SCHEMBL7793462 | 0.72 | MAPT (0.55) | LMNAALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL10967209 | 0.72 | POLB (0.50) | LMNAALDH1A1SMN1; SMN2TP53NPSR1 | |
| Hydrochloric Acid SCHEMBL10921886 | 0.72 | KMT2A (0.58) | LMNAALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL10925731 | 0.70 | PKM (0.52) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10921685 | 0.70 | ABCB1 (0.43) | LMNAALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL10915401 | 0.70 | ADRA1D (0.46) | KDM4ENPSR1 | |
| SCHEMBL10918581 | 0.70 | HTR1A (0.53) | LMNAALDH1A1MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064705-B1 | 5-AMINOMETHYL-2,3-DIHYDRO-2-OXO-1H-IMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4371737-A | CARDIOTONICS, ANTIHYPERTENSIUES AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-02-01 | — | — | US | disclosed |
| EP-0064705-A1 | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |