Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL6267680 | 0.70 | MEN1 (0.57) | MAPTALDH1A1FDPSHSD17B10MEN1 | |
| SCHEMBL12651086 | 0.67 | CES2 (0.35) | CES2CES1HDAC1LCKFYN | |
| Phosphoric Acid SCHEMBL22235246 | 0.67 | DRD2 (0.43) | CES2CES1MAPTALDH1A1HDAC6 | |
| Aniline SCHEMBL29573098 | 0.64 | TSHR (0.65) | FDPSTAAR1HSD17B10ALOX15TSHR | |
| Aniline SCHEMBL321169 | 0.64 | TSHR (0.65) | FDPSTAAR1HSD17B10ALOX15TSHR | |
| Aniline SCHEMBL675043 | 0.64 | TSHR (0.65) | FDPSTAAR1HSD17B10ALOX15TSHR | |
| Benzidine SCHEMBL7598479 | 0.64 | ALDH1A1 (0.65) | MAPTALDH1A1FDPSHPGDTAAR1 | |
| Aniline SCHEMBL5334646 | 0.64 | TSHR (0.65) | FDPSTAAR1HSD17B10ALOX15TSHR | |
| 4-Aminophenol SCHEMBL78547 | 0.62 | CYP3A4 (0.72) | MAPTALDH1A1GAAFDPSHPGD | |
| Aniline SCHEMBL28659856 | 0.62 | TSHR (0.61) | FDPSTAAR1HSD17B10ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410386-B | 2-alkenyl-3-aminothiophene derivative and process for producing the same | MITSUI CHEMICALS INC | 2013-07-24 | — | — | CN | disclosed |
| US-8153823-B2 | 2-alkenyl-3-aminothiophene derivative and process for producing thereof | MITSUI CHEMICALS, INC. (JP) | 2012-04-10 | — | — | US | disclosed |
| CN-101410386-A | 2-alkenyl-3-aminothiophene derivative and process for producing the same | MITSUI CHEMICALS INC (JP) | 2009-04-15 | — | — | CN | disclosed |
| US-20090082579-A1 | 2-ALKENYL-3-AMINOTHIOPHENE DERIVATIVE AND PROCESS FOR PRODUCING THEREOF | MITSUI CHEMICALS, INC. (JP) | 2009-03-26 | — | — | US | disclosed |
| EP-2011792-A1 | 2-ALKENYL-3-AMINOTHIOPHENE DERIVATIVE AND METHOD FOR PRODUCING THE SAME | Mitsui Chemicals, Inc. (JP) | 2009-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082579-A1 | 2-ALKENYL-3-AMINOTHIOPHENE DERIVATIVE AND PROCESS FOR PRODUCING THEREOF | ABAT, ALDH7A1, AADAT | KCNH2 968/4885CES2 941/4885CES1 1099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.