Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 9/20 | 0.69 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.69 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.69 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | RGS12 | O14924 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769670 | 0.86 | KCNH2 (0.59) | AKR1C3AKR1C2AKR1C4PTGS1PLA2G4A | |
| SCHEMBL7696757 | 0.82 | PLA2G2A (0.69) | AKR1C3AKR1C2AKR1C4PTGS1MTNR1A | |
| SCHEMBL2694527 | 0.81 | AKR1C3 (1.00) | AKR1C3AKR1C2AKR1C4PTGS1AR | |
| Methane SCHEMBL11569107 | 0.81 | AKR1C3 (0.98) | AKR1C3AKR1C2AKR1C4PTGS1AR | |
| SCHEMBL6952151 | 0.80 | PLA2G4A (0.56) | MTNR1AMTNR1BMAPTABCB1PLA2G4A | |
| SCHEMBL8644723 | 0.79 | AKR1C3 (0.72) | AKR1C3AKR1C2AKR1C4PTGS1MAPT | |
| SCHEMBL2685182 | 0.78 | MTNR1A (0.63) | AKR1C3AKR1C2AKR1C4PTGS1MTNR1A | |
| SCHEMBL20769657 | 0.76 | PLA2G4A (0.53) | AKR1C3AKR1C2AKR1C4PTGS1LMNA | |
| SCHEMBL10943893 | 0.75 | AKR1C3 (0.72) | AKR1C3AKR1C2AKR1C4PTGS1MEN1 | |
| SCHEMBL25100759 | 0.75 | HTR6 (0.62) | AKR1C3AKR1C2AKR1C4PTGS1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4532249-A | Derivatives of p-acylaminophenol having a therapeutic action, and compositions having a therapeutic action containing said derivatives as pharmacologically active ingredients | MOLNAR FRANCOIS (CH) | 1985-07-30 | — | — | US | disclosed |
| US-4242348-A | ANALGESICS; ANTIIFLAMMATORY AGENTS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1980-12-30 | — | — | US | disclosed |
| US-4196216-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | U.S. PHILIPS CORPORATION (US) | 1980-04-01 | — | — | US | disclosed |
| US-4071686-A | ANTIINFLAMMATORY, ANALGESIC | U.S. PHILIPS CORPORATION (US) | 1978-01-31 | — | — | US | disclosed |
| US-4044023-A | ANTIINFLAMMATORY, ANALGESICS | U.S. PHILIPS CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |