Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.64 |
| ▸ | IL1RN | P18510 | 1/20 | 0.64 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094118 | 0.81 | MEN1 (0.73) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL5514453 | 0.81 | MEN1 (0.69) | KEAP1KMT2AMEN1ALDH1A1PKM | |
| SCHEMBL31661903 | 0.81 | MEN1 (0.73) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL11882067 | 0.81 | KMT2A (0.61) | KEAP1KMT2AMEN1ALDH1A1CA1 | |
| SCHEMBL25031372 | 0.79 | KEAP1 (1.00) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL810795 | 0.79 | KMT2A (0.91) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| Phenyl(Phenylsulfonyl)Amine SCHEMBL114765 | 0.79 | KEAP1 (1.00) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL29955792 | 0.79 | PIK3CB (0.56) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL1990223 | 0.78 | KEAP1 (0.73) | KEAP1IL1RNERAP1KMT2AMEN1 | |
| SCHEMBL17868333 | 0.78 | PIK3CB (0.67) | KEAP1IL1RNERAP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354407-B2 | 2-anilino-4-(heterocyclic)amino-pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-15 | — | — | US | claimed |
| US-20090227586-A1 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-10 | — | — | US | claimed |
| CN-101506175-A | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha | BOEHRINGER INGELHEIM INT (DE) | 2009-08-12 | — | — | CN | claimed |
| EP-2054392-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | Boehringer Ingelheim International GmbH (DE) | 2009-05-06 | — | — | EP | claimed |
| WO-2007146981-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | claimed |
| US-20070293494-A1 | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines | DJUNG JANE F | 2007-12-20 | — | — | US | claimed |
| US-20150259327-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2015-09-17 | — | — | US | disclosed |
| US-9067922-B2 | Chemical compounds | PFIZER LIMITED (GB) | 2015-06-30 | — | — | US | disclosed |
| US-8907101-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2014-12-09 | — | — | US | disclosed |
| US-20140315878-A1 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2014-10-23 | — | — | US | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| US-20130338111-A1 | Sulfonamide Derivatives | ICAGEN, INC. (US) | 2013-12-19 | — | — | US | disclosed |
| US-8354407-B2 | 2-anilino-4-(heterocyclic)amino-pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-15 | — | — | US | disclosed |
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |
| US-20100197655-A1 | SULFONAMIDE DERIVATIVES | Pfizer Limited Icagen, Inc. | 2010-08-05 | — | — | US | disclosed |
| US-20090227586-A1 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-10 | — | — | US | disclosed |
| CN-101506175-A | 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase C-alpha | BOEHRINGER INGELHEIM INT (DE) | 2009-08-12 | — | — | CN | disclosed |
| EP-2054392-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | Boehringer Ingelheim International GmbH (DE) | 2009-05-06 | — | — | EP | disclosed |
| WO-2007146981-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |
| US-20070293494-A1 | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines | DJUNG JANE F | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293494-A1 | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines | PRKCA, PRKCG, PRKCH | KEAP1 1627/4885IL1RN 2371/4885ERAP1 897/4885 |
| US-20100197655-A1 | SULFONAMIDE DERIVATIVES | SULT2A1, SULT1A1, TPST2 | KEAP1 2261/4885IL1RN 3377/4885ERAP1 3890/4885 |
| US-20130338111-A1 | Sulfonamide Derivatives | SULT2A1, SULT1A1, TPST2 | KEAP1 2261/4885IL1RN 3377/4885ERAP1 3890/4885 |
| US-20090227586-A1 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES | PRKCA, PRKCG, PRKCH | KEAP1 1627/4885IL1RN 2371/4885ERAP1 897/4885 |
| US-20150259327-A1 | Chemical Compounds | SULT2A1, SULT1A1, SULT1E1 | KEAP1 3048/4885IL1RN 762/4885ERAP1 637/4885 |
| US-20140315878-A1 | CHEMICAL COMPOUNDS | SULT2A1, SULT1A1, SULT1E1 | KEAP1 3048/4885IL1RN 762/4885ERAP1 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.