Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 3/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10947750 | 0.89 | HSP90AA1 (0.44) | HSP90AA1BCL2L1MCL1NR3C1LMNA | |
| SCHEMBL11168235 | 0.84 | TSHR (0.43) | HSP90AA1TSHRMAPK1PTGESLMNA | |
| SCHEMBL11062225 | 0.82 | ERCC1 (0.46) | HSP90AA1TSHRMEN1KMT2A | |
| Benzamide SCHEMBL10949386 | 0.81 | PTGS1 (0.43) | HSP90AA1TSHRBCL2L1MCL1NR3C1 | |
| SCHEMBL10949391 | 0.81 | PTGS1 (0.43) | HSP90AA1PTGESNR3C1HPGDPDK1 | |
| SCHEMBL11166612 | 0.80 | HSP90AA1 (0.40) | HSP90AA1TSHRMAPK1PTGESLMNA | |
| SCHEMBL11041424 | 0.80 | HSP90AA1 (0.40) | HSP90AA1TSHRBCL2L1MCL1NR3C1 | |
| SCHEMBL21963902 | 0.70 | TSPO (0.49) | TSHRMAPK1BCL2L1MCL1NR3C1 | |
| SCHEMBL18216887 | 0.69 | LMNA (0.56) | TSHRPTGESLMNAHPGDMEN1 | |
| SCHEMBL10780367 | 0.68 | CYP2C19 (0.40) | TSHRNR3C1TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0082109-A2 | Substituted 2-hydroxyphenylacetic acids and derivatives of them | CIBA-GEIGY AG (CH) | 1983-06-22 | — | — | EP | claimed |
| US-4514415-A | ANALGESICS | CIBA GEIGY CORPORATION (US) | 1985-04-30 | — | — | US | disclosed |
| EP-0107620-A1 | Phenol derivatives | CIBA-GEIGY AG (CH) | 1984-05-02 | — | — | EP | disclosed |
| EP-0082109-A2 | Substituted 2-hydroxyphenylacetic acids and derivatives of them | CIBA-GEIGY AG (CH) | 1983-06-22 | — | — | EP | disclosed |
| EP-0078240-A2 | Lactones | CIBA-GEIGY AG (CH) | 1983-05-04 | — | — | EP | disclosed |
| EP-0078241-A2 | Furanes | CIBA-GEIGY AG (CH) | 1983-05-04 | — | — | EP | disclosed |