Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL10949386 | 0.92 | PTGS1 (0.43) | HSP90AA1PTGS1PTGS2TRPM8TSPO | |
| SCHEMBL10949391 | 0.91 | PTGS1 (0.43) | HSP90AA1PTGS1PTGS2KMT2AMEN1 | |
| SCHEMBL10950761 | 0.89 | HSP90AA1 (0.42) | HSP90AA1TSPOKMT2AMEN1NR3C1 | |
| SCHEMBL11062225 | 0.86 | ERCC1 (0.46) | HSP90AA1KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL11041424 | 0.83 | HSP90AA1 (0.40) | HSP90AA1TRPM8TSPOKMT2AMEN1 | |
| SCHEMBL21963902 | 0.73 | TSPO (0.49) | TRPM8TSPOKMT2ANR3C1CRHBP | |
| SCHEMBL11168235 | 0.72 | TSHR (0.43) | HSP90AA1KMT2AMEN1LMNAHPGD | |
| SCHEMBL10780367 | 0.71 | CYP2C19 (0.40) | TRPM8TSPONR3C1ALDH1A1L3MBTL1 | |
| SCHEMBL7002879 | 0.69 | CYP2C19 (0.49) | TRPM8TSPONR3C1CRHBPCRHR2 | |
| SCHEMBL22014036 | 0.69 | NR3C1 (0.48) | TRPM8TSPOKMT2AMEN1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0082109-A2 | Substituted 2-hydroxyphenylacetic acids and derivatives of them | CIBA-GEIGY AG (CH) | 1983-06-22 | — | — | EP | claimed |
| US-4514415-A | ANALGESICS | CIBA GEIGY CORPORATION (US) | 1985-04-30 | — | — | US | disclosed |
| US-4451462-A | Method of treating inflammation and pain using heteramino benzofurans | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0107620-A1 | Phenol derivatives | CIBA-GEIGY AG (CH) | 1984-05-02 | — | — | EP | disclosed |
| US-4426380-A | ANTIINFLAMMATORY, ANALGESIC, SUNSCREEN | CIBA-GEIGY CORPORATION (US) | 1984-01-17 | — | — | US | disclosed |
| EP-0082109-A2 | Substituted 2-hydroxyphenylacetic acids and derivatives of them | CIBA-GEIGY AG (CH) | 1983-06-22 | — | — | EP | disclosed |
| EP-0078240-A2 | Lactones | CIBA-GEIGY AG (CH) | 1983-05-04 | — | — | EP | disclosed |
| EP-0078241-A2 | Furanes | CIBA-GEIGY AG (CH) | 1983-05-04 | — | — | EP | disclosed |