Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Amidate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 0.97 |
| ▸ | GABRB2 known ✓ | P47870 | 6/20 | 0.97 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.97 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amidate SCHEMBL39485 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| S-Etomidate SCHEMBL39486 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Etomidate SCHEMBL39487 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL1817757 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Etomidate SCHEMBL11323863 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL1098161 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL901536 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL21773562 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL22502728 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL11235297 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112469707-B | Preventive or therapeutic agent for spinal muscular atrophy | 利伯纳生物科学株式会社 | 2024-06-21 | — | — | CN | disclosed |
| WO-2024081263-A1 | DEPOSITION OF METAL-CONTAINING FILMS | LAM RESEARCH CORPORATION (US) | 2024-04-18 | — | — | WO | disclosed |
| US-20240052486-A1 | PRECURSORS FOR DEPOSITION OF MOLYBDENUM-CONTAINING FILMS | LAM RES CORP (US) | 2024-02-15 | — | — | US | disclosed |
| WO-2023250500-A1 | PLASMA ENHANCED LOW TEMPERATURE ATOMIC LAYER DEPOSITION OF METALS | LAM RESEARCH CORPORATION (US) | 2023-12-28 | — | — | WO | disclosed |
| US-11821071-B2 | Precursors for deposition of molybdenum-containing films | LAM RESEARCH CORPORATION (US) | 2023-11-21 | — | — | US | disclosed |
| WO-2023114640-A1 | DEPOSITION OF METALS IN RECESSED FEATURES WITH THE USE OF HALOGEN-CONTAINING DEPOSITION INHIBITORS | LAM RESEARCH CORPORATION (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114648-A1 | LOW TEMPERATURE MOLYBDENUM DEPOSITION ASSISTED BY SILICON-CONTAINING REACTANTS | LAM RESEARCH CORPORATION (US) | 2023-06-22 | — | — | WO | disclosed |
| US-20220170155-A1 | PRECURSORS FOR DEPOSITION OF MOLYBDENUM-CONTAINING FILMS | LAM RESEARCH CORPORATION | 2022-06-02 | — | — | US | disclosed |
| WO-2020185618-A1 | PRECURSORS FOR DEPOSITION OF MOLYBDENUM-CONTAINING FILMS | LAM RESEARCH CORPORATION (US) | 2020-09-17 | — | — | WO | disclosed |
| US-8642797-B2 | Amidate precursors for depositing metal containing films | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120045589-A1 | Amidate Precursors For Depositing Metal Containing Films | AIR PRODUCTS AND CHEMICALS, INC. (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120045589-A1 | Amidate Precursors For Depositing Metal Containing Films | TERT, METTL3, TAF5 | GABRA1 2380/4885GABRB2 2368/4885GABRA2 2711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.