SCHEMBL10986984

SCHEMBL10986984

CC(Cl)C1CN(c2cccc(C(F)(F)F)c2)C(=O)C1(Cl)Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
TP53 P04637 1/20 0.41
MAPT P10636 1/20 0.41
TSHR P16473 1/20 0.41
NFKB1 P19838 1/20 0.41
RAB9A P51151 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPK1 P28482 1/20 0.39
HSD17B10 Q99714 1/20 0.39
OPRM1 P35372 1/20 0.39
OPRL1 P41146 1/20 0.39
NOTUM Q6P988 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9683395 0.80 AR (0.44) ARSMN1; SMN2NPC1TP53MAPT
SCHEMBL9797233 0.79 AR (0.49) ARSMN1; SMN2NPC1TP53MAPT
SCHEMBL9735938 0.78 AR (0.42) ARSMN1; SMN2NPC1TP53MAPT
SCHEMBL10986074 0.75 ALOX5 (0.41) ARSMN1; SMN2NPC1TP53MAPT
SCHEMBL10986755 0.74 AR (0.46) ARMEN1KMT2AALDH1A1KDM4E
SCHEMBL10652687 0.71 DRD2 (0.41) ARSMN1; SMN2MEN1KMT2ANOTUM
SCHEMBL10406730 0.70 NOTUM (0.43) ARMAPTMEN1KMT2AALDH1A1
SCHEMBL8577305 0.70 ALDH1A1 (0.61) ARSMN1; SMN2NPC1TP53MAPT
SCHEMBL1082991 0.68 SMN1; SMN2 (0.49) SMN1; SMN2NPC1TP53MAPTTSHR
SCHEMBL8109561 0.67 ALDH1A1 (0.48) SMN1; SMN2NPC1TP53MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4505737-A HALOGENATED PHENYLPYRROLIDONE AND HALOALKYLPHOSPHONIC ACID STAUFFER CHEMICAL COMPANY (US) 1985-03-19 US disclosed
US-4428767-A A PYRROLIDONE AND A CYCLOHEXENEDIONE STAUFFER CHEMICAL COMPANY (US) 1984-01-31 US disclosed
US-4416684-A PYRROLIDONE AND M-UREIDOPHENYL CARBAMATE STAUFFER CHEMICAL COMPANY (US) 1983-11-22 US disclosed
US-4317673-A MIXTURE OF /-TRIFLUOROPHENYL; 3-CHLORO, 4-CHLOROMETHYL-2-PYRROLIDONE AND AN N-P-CHLOROPHENOXYPHENYL-N*,N*-DIALKYL UREA STAUFFER CHEMICAL COMPANY (US) 1982-03-02 US disclosed
EP-0015453-B1 SYNERGISTIC HERBICIDAL COMPOSITIONS AND METHOD FOR CONTROLLING UNDESIRABLE VEGETATION STAUFFER CHEMICAL COMPANY (US) 1981-11-04 EP disclosed
US-4263038-A 3-AMINO-TRIAZOLE AND A PYRROLIDONE STAUFFER CHEMICAL COMPANY (US) 1981-04-21 US disclosed
EP-0015453-A2 Synergistic herbicidal compositions and method for controlling undesirable vegetation STAUFFER CHEMICAL COMPANY (US) 1980-09-17 EP disclosed
US-4210589-A CYCLIZATION STAUFFER CHEMICAL COMPANY (US) 1980-07-01 US disclosed
US-4110105-A Aromatic N-substituted halo-substituted-2-pyrrolidinones and their utility as herbicides STAUFFER CHEMICAL COMPANY (US) 1978-08-29 US disclosed