Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18539295 | 1.00 | LMNA (0.55) | LMNAHTTALDH1A1IDO1KMT2A | |
| SCHEMBL18539244 | 1.00 | LMNA (0.55) | LMNAHTTALDH1A1IDO1KMT2A | |
| SCHEMBL18539280 | 0.88 | PDPK1 (0.66) | IDO1PDPK1ADRA2BADRA2CADRA1A | |
| SCHEMBL31388654 | 0.88 | PDPK1 (0.66) | IDO1PDPK1ADRA2BADRA2CADRA1A | |
| SCHEMBL1691714 | 0.88 | PDPK1 (0.66) | IDO1PDPK1ADRA2BADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL7141983 | 0.86 | PDPK1 (0.63) | IDO1PDPK1ADRA2BADRA2CADRA1A | |
| SCHEMBL2115700 | 0.84 | HTT (0.63) | LMNAHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL61094 | 0.81 | PDPK1 (0.79) | LMNAHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL6344102 | 0.81 | HTT (0.59) | LMNAHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL61380 | 0.81 | PDPK1 (0.79) | LMNAHTTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952031-B2 | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-02-10 | — | — | US | disclosed |
| US-8952031-B2 | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-02-10 | — | — | US | disclosed |
| US-8952031-B2 | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-02-10 | — | — | US | disclosed |
| EP-2280933-B1 | 2 -AMINOTETRALIN DERIVATIVES AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE INC (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20120165360-A1 | AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165360-A1 | AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-8153686-B2 | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists | THERAVANCE, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153686-B2 | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists | THERAVANCE, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153686-B2 | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists | THERAVANCE, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| EP-2280933-A1 | 2 -AMINOTETRALIN DERIVATIVES AS MU OPIOID RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| EP-2280933-A1 | 2 -AMINOTETRALIN DERIVATIVES AS MU OPIOID RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009124022-A1 | 2 -AMINOTETRALIN DERIVATIVES AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2009-10-08 | — | — | WO | disclosed |
| WO-2009124022-A1 | 2 -AMINOTETRALIN DERIVATIVES AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2009-10-08 | — | — | WO | disclosed |
| US-20090247627-A1 | AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2009-10-01 | — | — | US | disclosed |
| US-20090247627-A1 | AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE BIOPHARMA R&D IP, LLC | 2009-10-01 | — | — | US | disclosed |
| US-6525222-B2 | By reacting aldehydes or ketones at high temperature and pressure with ammonia, amines and hydrogen in the presence of a catalyst mixed oxide of zirconium, copper, nickel, cobalt, and optionally molybdenum, aluminum and manganese | BASF AKTIENGESELLSCHAFT (DE) | 2003-02-25 | — | — | US | disclosed |
| US-20010003136-A1 | Process for preparing amines | BASF AKTIENGESELLSCHAFT (DE) | 2001-06-07 | — | — | US | disclosed |
| EP-0073960-A1 | 2-Arylhydrazino-2-imidazolines, their acyl derivatives, process for their preparation and their use in the control of endoparasites and ectoparasites | BAYER AG (DE) | 1983-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010003136-A1 | Process for preparing amines | AOC2, AOC3, SOD1 | LMNA 3670/4885HTT 3635/4885ALDH1A1 1280/4885 |
| US-20120165360-A1 | AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | OPRL1, OPRM1, OPRD1 | LMNA 4668/4885HTT 1009/4885ALDH1A1 1590/4885 |
| US-20090247627-A1 | AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | OPRL1, OPRM1, OPRD1 | LMNA 4668/4885HTT 1009/4885ALDH1A1 1590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.