Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 15/20 | 0.54 |
| ▸ | CYP2E1 | P05181 | 14/20 | 0.54 |
| ▸ | CYP2C8 | P10632 | 14/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 14/20 | 0.54 |
| ▸ | CYP2B6 | P20813 | 14/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.54 |
| ▸ | BRS3 | P32247 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672276 | 0.87 | CYP2E1 (0.70) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL14495707 | 0.85 | CYP2C19 (0.52) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL13651209 | 0.83 | CYP2E1 (0.78) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL22668144 | 0.83 | CYP2E1 (0.53) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL1170729 | 0.82 | ALDH1A1 (0.57) | CYP2C19CYP1A2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL14496038 | 0.81 | CYP1A2 (0.46) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15693611 | 0.79 | RAB9A (0.76) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL1286065 | 0.77 | KDM4E (0.57) | CYP2C19CYP1A2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL31578181 | 0.77 | ALDH1A1 (0.50) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL4597359 | 0.77 | ALDH1A1 (0.53) | CYP2C19CYP2E1CYP2C8CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220016099-A1 | BENZIMIDAZOLE OR BENZOXAZOLE DERIVATIVES FOR PREVENTING AND TREATING CENTRAL NERVOUS SYSTEM DISEASE, DIABETES, AND COMPLICATIONS THEREOF | TRINUERO (KR) | 2022-01-20 | — | — | US | claimed |
| WO-2020116742-A1 | BENZIMIDAZOLE OR BENZOXAZOLE DERIVATIVES FOR PREVENTING AND TREATING CENTRAL NERVOUS SYSTEM DISEASE, DIABETES, AND COMPLICATIONS THEREOF | 주식회사 트리뉴로 | 2020-06-11 | — | — | WO | claimed |
| US-20220016099-A1 | BENZIMIDAZOLE OR BENZOXAZOLE DERIVATIVES FOR PREVENTING AND TREATING CENTRAL NERVOUS SYSTEM DISEASE, DIABETES, AND COMPLICATIONS THEREOF | TRINUERO (KR) | 2022-01-20 | — | — | US | disclosed |
| CN-110573605-B | Slow rhizobium monooxygenase and application thereof in preparation of chiral sulfoxide | 华东理工大学 | 2021-11-19 | — | — | CN | disclosed |
| US-10787651-B2 | Bradyrhizobium monooxygenase and use thereof for preparation of chiral sulfoxide | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2020-09-29 | — | — | US | disclosed |
| US-10787651-B2 | Bradyrhizobium monooxygenase and use thereof for preparation of chiral sulfoxide | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2020-09-29 | — | — | US | disclosed |
| WO-2020116742-A1 | BENZIMIDAZOLE OR BENZOXAZOLE DERIVATIVES FOR PREVENTING AND TREATING CENTRAL NERVOUS SYSTEM DISEASE, DIABETES, AND COMPLICATIONS THEREOF | 주식회사 트리뉴로 | 2020-06-11 | — | — | WO | disclosed |
| US-20200140830-A1 | BRADYRHIZOBIUM MONOOXYGENASE AND USE THEREOF FOR PREPARATION OF CHIRAL SULFOXIDE | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2020-05-07 | — | — | US | disclosed |
| US-20200140830-A1 | BRADYRHIZOBIUM MONOOXYGENASE AND USE THEREOF FOR PREPARATION OF CHIRAL SULFOXIDE | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2020-05-07 | — | — | US | disclosed |
| CN-110573605-A | Slow rhizobium monooxygenase and application thereof in preparation of chiral sulfoxide | 华东理工大学 | 2019-12-13 | — | — | CN | disclosed |
| WO-2019169695-A1 | BRADYRHIZOBIUM MONOOXYGENASE AND APPLICATION THEREOF IN PREPARATION OF CHIRAL SULFOXIDE | 华东理工大学 | 2019-09-12 | — | — | WO | disclosed |
| US-7615563-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-10 | — | — | US | disclosed |
| US-7615563-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED | 2009-11-10 | — | — | US | disclosed |
| US-20060025415-A1 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED | 2006-02-02 | — | — | US | disclosed |
| US-20060025415-A1 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED | 2006-02-02 | — | — | US | disclosed |
| EP-0931790-B1 | Method for producing 2-sulfonylpyridine derivates and method for producing 2-( (2-pyridyl)methyl)thio)-1H-benzimidazole derivates | KURARAY CO (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6350876-B2 | REACTING SULFONYL CYANIDE DERIVATIVE WITH ALPHA,BETA-UNSAT-URATED CARBONYL COMPOUND; ORGANOLITHIUM COMPOUND; STARTING MATERIAL/INTERMEDIATE FOR DRUG SYNTHESIS (ANTI-PARKINSON'S DRUG LAZABEMIDE) AND AGRICULTURAL CHEMICALS (PESTICIDES) | KURARAY CO., LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| US-20010051726-A1 | Method for producing 2-sulfonylpyridine derivatives and method for producing 2- { [ (2-pyridyl) methyl] thio} -1H-benzimidazole derivatives | KURARAY CO., LTD. (JP) | 2001-12-13 | — | — | US | disclosed |
| US-6197962-B1 | REACTING A,B-UNSATURATED CARBONYL COMPOUND WITH A SULFONYL CYANIDE; CYCLIZATION | KURARAY CO., LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-0931790-A2 | Method for producing 2-sulfonylpyridine derivates and method for producing 2-( (2-pyridyl)methyl)thio)-1H-benzimidazole derivates | KURARAY CO., LTD. (JP) | 1999-07-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025415-A1 | Compositions useful as inhibitors of voltage-gated sodium channels | SCNN1G, KCNN3, KCNN2 | CYP2C19 4313/4885CYP2E1 4653/4885CYP2C8 4126/4885 |
| US-20010051726-A1 | Method for producing 2-sulfonylpyridine derivatives and method for producing 2- { [ (2-pyridyl) methyl] thio} -1H-benzimidazole derivatives | PDXK, KCNJ2, KCNJ1 | CYP2C19 1175/4885CYP2E1 417/4885CYP2C8 1591/4885 |
| US-20220016099-A1 | BENZIMIDAZOLE OR BENZOXAZOLE DERIVATIVES FOR PREVENTING AND TREATING CENTRAL NERVOUS SYSTEM DISEASE, DIABETES, AND COMPLICATIONS THEREOF | KEAP1, SLC5A1, GCLC | CYP2C19 1226/4885CYP2E1 287/4885CYP2C8 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.