Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 15/20 | 0.78 |
| ▸ | CYP2C8 | P10632 | 15/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 15/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 15/20 | 0.78 |
| ▸ | CYP2B6 | P20813 | 15/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.78 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | BRS3 | P32247 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592737 | 0.87 | RAB9A (0.77) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL15693611 | 0.84 | RAB9A (0.76) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL9743293 | 0.84 | CYP2E1 (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL22468988 | 0.84 | CYP2E1 (0.81) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL1101910 | 0.83 | CYP2C19 (0.54) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL8768278 | 0.82 | LMNA (0.79) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL4650009 | 0.82 | CYP2E1 (0.81) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL13381572 | 0.82 | NPC1 (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL14495707 | 0.81 | CYP2C19 (0.52) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL15693621 | 0.81 | NPC1 (0.81) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230018423-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT AND/OR PREVENTION OF DISEASES AND DISORDERS MEDIATED BY NLRP3 | YODA THERAPEUTICS INC. (TW) | 2023-01-19 | — | — | US | disclosed |
| US-11370775-B2 | Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors | Tseng, Yufeng Jane (US) | 2022-06-28 | — | — | US | disclosed |
| US-20200361894-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) | 2020-11-19 | — | — | US | disclosed |
| US-20090253911-A1 | New Compounds Useful for the Synthesis of S- and R-Omeprazole and a Process for Their Preparation | VON UNGE SVERKER | 2009-10-08 | — | — | US | disclosed |
| US-20080255199-A1 | Compounds Useful for the Synthesis of S- and R-Omeprazole and a Process for Their Preparation | ASTRAZENECA AB (SE) | 2008-10-16 | — | — | US | disclosed |
| US-20070161682-A1 | Compounds Useful for the Synthesis of S- and R-Omeprazole and a Process for their Preparation | UNGE SVERKER V | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230018423-A1 | BENZIMIDAZOLE DERIVATIVES FOR TREATMENT AND/OR PREVENTION OF DISEASES AND DISORDERS MEDIATED BY NLRP3 | NLRP3, NOD1, NLRP1 | CYP2E1 269/4885CYP2C8 390/4885CYP2D6 699/4885 |
| US-11370775-B2 | Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors | DAO, DDO, IL4I1 | CYP2E1 145/4885CYP2C8 415/4885CYP2D6 176/4885 |
| US-20070161682-A1 | Compounds Useful for the Synthesis of S- and R-Omeprazole and a Process for their Preparation | TPMT, RPS4X, MRPS34 | CYP2E1 32/4885CYP2C8 51/4885CYP2D6 16/4885 |
| US-20080255199-A1 | Compounds Useful for the Synthesis of S- and R-Omeprazole and a Process for Their Preparation | TPMT, MRPS34, RPS4X | CYP2E1 50/4885CYP2C8 44/4885CYP2D6 21/4885 |
| US-20200361894-A1 | NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS | DAO, DDO, DDC | CYP2E1 302/4885CYP2C8 598/4885CYP2D6 417/4885 |
| US-20090253911-A1 | New Compounds Useful for the Synthesis of S- and R-Omeprazole and a Process for Their Preparation | TPMT, RPS4X, MRPS34 | CYP2E1 49/4885CYP2C8 70/4885CYP2D6 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.