Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 16/20 | 0.70 |
| ▸ | CYP2C8 | P10632 | 16/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 16/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 16/20 | 0.70 |
| ▸ | CYP2B6 | P20813 | 16/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 16/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 15/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.70 |
| ▸ | BRS3 | P32247 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17153978 | 0.88 | CYP2E1 (0.72) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL1101910 | 0.87 | CYP2C19 (0.54) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL14304388 | 0.80 | CYP2E1 (0.90) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL20982659 | 0.78 | NPC1 (0.85) | HPGDSMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL29439014 | 0.77 | KDM4E (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL4371528 | 0.77 | KDM4E (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL4597364 | 0.77 | ALDH1A1 (0.67) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL8768283 | 0.77 | LMNA (0.97) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL4650010 | 0.77 | CYP2E1 (1.00) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL10220063 | 0.77 | CYP2E1 (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573605-B | Slow rhizobium monooxygenase and application thereof in preparation of chiral sulfoxide | 华东理工大学 | 2021-11-19 | — | — | CN | disclosed |
| US-10787651-B2 | Bradyrhizobium monooxygenase and use thereof for preparation of chiral sulfoxide | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2020-09-29 | — | — | US | disclosed |
| US-20200140830-A1 | BRADYRHIZOBIUM MONOOXYGENASE AND USE THEREOF FOR PREPARATION OF CHIRAL SULFOXIDE | JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. (CN) | 2020-05-07 | — | — | US | disclosed |
| CN-110573605-A | Slow rhizobium monooxygenase and application thereof in preparation of chiral sulfoxide | 华东理工大学 | 2019-12-13 | — | — | CN | disclosed |
| US-20170326104-A1 | IRE-1ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH, INC. (CN) | 2017-11-16 | — | — | US | disclosed |
| US-20110245231-A1 | ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION FOR TREATING ALCOHOL DEPENDENCE, AND A METHOD FOR OBTAINING AND THE USE OF SAID ACTIVE SUBSTANCE | ALLA CHEM, LLC (US) | 2011-10-06 | — | — | US | disclosed |
| US-6350876-B2 | REACTING SULFONYL CYANIDE DERIVATIVE WITH ALPHA,BETA-UNSAT-URATED CARBONYL COMPOUND; ORGANOLITHIUM COMPOUND; STARTING MATERIAL/INTERMEDIATE FOR DRUG SYNTHESIS (ANTI-PARKINSON'S DRUG LAZABEMIDE) AND AGRICULTURAL CHEMICALS (PESTICIDES) | KURARAY CO., LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170326104-A1 | IRE-1ALPHA INHIBITORS | ERN1, XBP1, ERN2 | CYP2E1 1761/4885CYP2C8 3212/4885CYP2D6 2832/4885 |
| US-20110245231-A1 | ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION FOR TREATING ALCOHOL DEPENDENCE, AND A METHOD FOR OBTAINING AND THE USE OF SAID ACTIVE SUBSTANCE | ADH1C, ADH1A, ADH5 | CYP2E1 10/4885CYP2C8 138/4885CYP2D6 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.