Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020728 | 0.88 | AMY1A (0.48) | AMY1AMAPTSMN1; SMN2TP53KDM4E | |
| SCHEMBL11019903 | 0.87 | AMY1A (0.47) | AMY1AHDAC6MAPTSMN1; SMN2TP53 | |
| SCHEMBL11022045 | 0.87 | AMY1A (0.47) | AMY1A | |
| SCHEMBL11017268 | 0.85 | CHEK2 (0.47) | AMY1ACDK2HDAC6MAPTSMN1; SMN2 | |
| SCHEMBL11018142 | 0.82 | AMY1A (0.43) | AMY1AHDAC6MAPTSMN1; SMN2TP53 | |
| SCHEMBL11019266 | 0.82 | AMY1A (0.43) | AMY1ACDK1MAPTSMN1; SMN2TP53 | |
| SCHEMBL11020382 | 0.76 | NPC1 (0.42) | AMY1ACDK1CDK2MKNK1MKNK2 | |
| SCHEMBL11019293 | 0.76 | AMY1A (0.49) | AMY1AFASNRHEB | |
| SCHEMBL11019017 | 0.76 | HPSE (0.42) | MAPTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL11017894 | 0.75 | CHEK2 (0.43) | AMY1AMAPTSMN1; SMN2TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |