Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019017 | 0.90 | HPSE (0.42) | CHEK2MAPTTP53SMN1; SMN2HPSE | |
| SCHEMBL11019903 | 0.89 | AMY1A (0.47) | AMY1AMAPTTP53SMN1; SMN2DGAT1 | |
| SCHEMBL11018142 | 0.89 | AMY1A (0.43) | AMY1AMAPTTP53SMN1; SMN2DGAT1 | |
| SCHEMBL11020728 | 0.88 | AMY1A (0.48) | CHEK2AMY1AMAPTTP53SMN1; SMN2 | |
| SCHEMBL11022045 | 0.87 | AMY1A (0.47) | CHEK2AMY1A | |
| SCHEMBL11020368 | 0.85 | AMY1A (0.46) | AMY1AMAPTTP53SMN1; SMN2CDK2 | |
| SCHEMBL11019266 | 0.82 | AMY1A (0.43) | AMY1AMAPTTP53SMN1; SMN2 | |
| SCHEMBL11019649 | 0.77 | RHEB (0.44) | AMY1AMAPTSMN1; SMN2HDAC6HDAC3 | |
| SCHEMBL11017271 | 0.76 | NPC1 (0.47) | CHEK2TP53SMN1; SMN2CDK4CCNA2 | |
| SCHEMBL11019293 | 0.76 | AMY1A (0.49) | CHEK2AMY1ARHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |