Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | OGT | O15294 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021741 | 0.92 | ATR (0.44) | MAPTALDH1A1SMN1; SMN2NPSR1OGT | |
| SCHEMBL11018857 | 0.89 | MAPT (0.44) | MAPTALDH1A1PDE5AATRPOLB | |
| SCHEMBL11022213 | 0.89 | ATR (0.44) | MAPTTRPV4PDE5AATRGUSB | |
| SCHEMBL11021081 | 0.88 | CA12 (0.43) | MAPTTRPV4PDE5AATRGUSB | |
| SCHEMBL11021236 | 0.86 | KDM4E (0.42) | MAPTALDH1A1SMN1; SMN2NPSR1OGT | |
| SCHEMBL11022217 | 0.81 | ATR (0.53) | MAPTTRPV4ATR | |
| SCHEMBL11018866 | 0.81 | MAPT (0.44) | MAPTALDH1A1SMN1; SMN2ATRGAA | |
| SCHEMBL11021552 | 0.81 | L3MBTL1 (0.47) | MAPTALDH1A1SMN1; SMN2PDE5APOLB | |
| SCHEMBL11021091 | 0.80 | ATR (0.48) | MAPTALDH1A1SMN1; SMN2TRPV4ATR | |
| SCHEMBL10763275 | 0.80 | MAPK10 (0.42) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |